【摘要】：目的探討炎癥標志物與精神分裂癥患者攻擊行為的相關(guān)性。方法以精神分裂癥患者為研究對象,所有患者均處于急性發(fā)作期。依據(jù)既往暴力史和修訂版外顯攻擊行為量表(MOAS)加權(quán)總分區(qū)分攻擊組(n=70)和非攻擊組(n=40)。采用陽性與陰性癥狀量表(PANSS)評估臨床癥狀,白細胞(WBC)、中性粒細胞(N)、C反應(yīng)蛋白(CRP)、白細胞介素-6(IL-6)作為炎癥標志物,比較兩組臨床癥狀與炎癥標志物的差異,并對MOAS與PANSS總分、分量表評分及炎癥標志物作相關(guān)分析。結(jié)果攻擊組MOAS加權(quán)總分、言語攻擊、對財產(chǎn)的攻擊與體力攻擊的評分均高于非攻擊組,差異均有統(tǒng)計學意義(P0.01)。攻擊組PANSS總分、陽性癥狀評分均高于非攻擊組,差異均有統(tǒng)計學意義(P0.05)。兩組WBC、N計數(shù)比較,差異無統(tǒng)計學意義(P0.05)。攻擊組CRP、IL-6水平均高于非攻擊組,差異均有統(tǒng)計學意義(P0.01)。MOAS加權(quán)總分與PANSS總分、陽性癥狀評分、一般精神病理評分、WBC計數(shù)、CRP及IL-6水平呈正相關(guān)(P0.05)。言語攻擊與陽性癥狀評分、CRP及IL-6水平呈正相關(guān)(P0.05),與陰性癥狀評分呈負相關(guān)(P0.01)。對財產(chǎn)的攻擊與WBC計數(shù)、CRP及IL-6水平呈正相關(guān)(P0.05)。自身攻擊與一般精神病理評分,WBC、N計數(shù),CRP及IL-6水平呈正相關(guān)(P0.05)。體力攻擊與PANSS總分、陽性癥狀評分、一般精神病理評分、CRP及IL-6水平呈正相關(guān)(P0.05)。結(jié)論攻擊組與非攻擊組相比,攻擊行為體現(xiàn)在言語攻擊、對財產(chǎn)的攻擊與體力攻擊方面。PANSS總分、陽性癥狀評分、CRP及IL-6水平可能與精神分裂癥患者攻擊行為相關(guān)。WBC、N計數(shù)與精神分裂癥患者攻擊行為不相關(guān)。
[Abstract]:Objective to investigate the correlation between inflammatory markers and aggressive behavior in schizophrenic patients. Methods all the patients with schizophrenia were in acute attack. According to the past violence history and the revised explicit aggression behavior scale (MOAS) weighted total score, the group of aggression (nong 70) and the group of non aggression (n 40) were distinguished. The positive and negative symptom scale (PANSS) was used to evaluate the clinical symptoms, and the leukocyte (WBC), neutrophil (N) C-reactive protein (CRP), interleukin-6 (IL-6) was used as the inflammatory marker. The differences between the clinical symptoms and the inflammatory markers were compared between the two groups, and the total scores of MOAS and PANSS were compared. The score of subscale and inflammatory markers were analyzed. Results the scores of MOAS weighted total score, speech attack, property attack and physical attack in the attack group were higher than those in the non-attack group, and the difference was statistically significant (P0.01). The total score of PANSS and the score of positive symptoms in the attack group were higher than those in the non-attack group, and the difference was statistically significant (P0.05). There was no significant difference in WBC,N count between the two groups (P0.05). The level of CRP,IL-6 in attack group was higher than that in non-attack group, the difference was statistically significant (P0.01). The weighted total score of MOAS was positively correlated with total score of PANSS, positive symptom score, general psychopathology score and IL-6 level (P0.05). Verbal aggression was positively correlated with positive symptom score and IL-6 level (P0.05), and negatively correlated with negative symptom score (P0.01). The attack on property was positively correlated with WBC count and IL-6 level (P0.05). There was a positive correlation between self attack and general psychopathologic score, WBC C N count and IL-6 level (P 0.05). There was a positive correlation between physical aggression and total score of PANSS, positive symptom score, general psychopathology score and IL-6 level (P0.05). Conclusion compared with the non-attack group, the aggressive behavior of the attack group is the total score of speech attack, attack on property and physical attack, and the total score of PANSS. Positive symptom score and IL-6 level may not be related to aggressive behavior of schizophrenia patients. WBCU N count is not related to aggressive behavior of schizophrenic patients.
【作者單位】： 中山市第三人民醫(yī)院早期干預(yù)科;
【基金】：中山市衛(wèi)生局醫(yī)學科研立項課題(編號:2013J149)
【分類號】：R749.3

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