靜息態(tài)BOLD-fMRI在輕度認(rèn)知障礙和阿爾茨海默病中的應(yīng)用
發(fā)布時間：2018-09-11 17:45
【摘要】：目的：應(yīng)用靜息態(tài)BOLD-fMRI成像技術(shù)，比較認(rèn)知功能正常的老年人、aMCI患者和AD患者與后扣帶回（PCC）相關(guān)的默認(rèn)網(wǎng)絡(luò)結(jié)構(gòu)的差異，探討靜息態(tài)BOLD-fMRI在MCI患者和AD患者中的應(yīng)用，為aMCI及AD的早期診斷提供影像依據(jù)。 方法：收集就診于山西醫(yī)科大學(xué)第一醫(yī)院神經(jīng)內(nèi)科臨床疑診為aMCI患者10例，男4例，女6例，年齡63～78歲，平均年齡69.3歲；疑診為AD患者10例，男6例，女4例，年齡65～80歲，平均年齡71.9歲；選取與AD組及aMCI組性別、年齡及受教育程度相匹配的健康志愿者10例，男7例，女3例，年齡60～75歲，平均年齡67.8歲。行頭顱常規(guī)MRI檢查除外腦外傷、腦出血、腦梗塞、腦腫瘤及顱腦手術(shù)等神經(jīng)系統(tǒng)疾病。所有受試者行靜息態(tài)BOLD-fMRI檢查，以PCC為種子區(qū)，進行與全腦其他區(qū)域基于體素的時間序列相關(guān)分析。經(jīng)獲得激活腦區(qū)閾值設(shè)為經(jīng)校正的P0.05，激活腦區(qū)體素范圍10。 結(jié)果：①正常對照組、aMCI組和AD組在年齡、性別、受教育程度方面差異無統(tǒng)計學(xué)意義，MMSE評分在三組之間差異有統(tǒng)計學(xué)意義。②正常對照組與PCC有功能連接的腦區(qū)包括：前額葉內(nèi)側(cè)區(qū)、雙側(cè)海馬、丘腦背側(cè)、楔葉及楔前葉、頂下小葉、部分顳葉、雙側(cè)小腦半球及小腦蚓部，網(wǎng)絡(luò)結(jié)構(gòu)的對稱性良好，連通性完整。③aMCI組所顯示的與PCC有功能連接的腦區(qū)和正常對照組相似，但是激活腦區(qū)的體素減少，網(wǎng)絡(luò)結(jié)構(gòu)連通性減弱。④AD組與PCC有功能連接性的腦區(qū)包括：雙側(cè)前額葉內(nèi)側(cè)區(qū)、楔葉及楔前葉、頂下小葉、部分顳葉等，，激活腦區(qū)的部位及范圍較正常對照組明顯減少，雙側(cè)海馬未見激活，網(wǎng)絡(luò)結(jié)構(gòu)存在減弱和斷裂。 結(jié)論：BOLD-fMRI技術(shù)作為一種新的MRI成像方法，使磁共振檢查不再局限于人腦形態(tài)學(xué)的研究，已經(jīng)延伸到腦功能成像的領(lǐng)域，為我們更好的研究腦功能提供了方法。靜息態(tài)默認(rèn)網(wǎng)絡(luò)的提出為我們診斷AD開拓了新思路，AD認(rèn)為是一種“失連接狀態(tài)”，MCI患者和AD患者腦內(nèi)默認(rèn)網(wǎng)絡(luò)功能的連通性出現(xiàn)減弱和斷裂，為aMCI及AD的早期診斷提供了依據(jù)。
[Abstract]:Objective: to compare the difference of the default network structure of (PCC) related to posterior cingulate gyrus (PCC) between elderly patients with normal cognitive function and patients with AD by using resting BOLD-fMRI imaging, and to explore the application of resting BOLD-fMRI in MCI patients and AD patients. To provide imaging evidence for early diagnosis of aMCI and AD. Methods: ten patients with suspected aMCI were collected from Department of Neurology, first Hospital of Shanxi Medical University, including 4 males and 6 females, aged 63 to 78 years, with an average age of 69.3 years, 10 suspected AD patients, 6 males and 4 females. Ten healthy volunteers, 7 males and 3 females, with an average age of 60.75 years, were selected to match the sex, age and education level of AD and aMCI groups, with an average age of 67.8 years. Brain injury, cerebral hemorrhage, cerebral infarction, brain tumor, craniocerebral surgery and other nervous system diseases were excluded by routine cranial MRI. Resting BOLD-fMRI was performed in all subjects, and PCC was used as seed area to analyze the correlation between PCC and voxel based time series in other regions of the brain. The threshold value of activated brain area was set to the corrected P0.05, and the voxel range of activated brain region was 10. 05%. Results the age, sex and sex of the normal control group, MCI group and AD group, There was no significant difference in education level among the three groups. 2 the functional connections between normal control group and PCC included medial prefrontal area, bilateral hippocampus, dorsal thalamus, cuneiform lobe and precuneiform lobe. In the subparietal lobules, part of temporal lobes, bilateral cerebellar hemispheres and cerebellar vermis, the symmetry of the network structure was good, and the brain regions with functional connections with PCC showed similar to those in the normal control group, but the voxins in the activated brain regions were decreased. In the group of weak connectivity of network structure, the functional connectivity between AD and PCC included: bilateral medial prefrontal lobe, cuneiform and precuneiform lobe, inferior parietal lobule, part of temporal lobe, etc. The sites and areas of activation in AD group were significantly less than those in normal control group. No activation was found in the bilateral hippocampus, and the network structure was weakened and broken. Conclusion as a new method of MRI imaging, the study of brain morphology has been extended to the field of brain function imaging, which provides a better method for us to study brain function. The establishment of resting default network opens up a new way for us to diagnose AD. AD is considered to be a kind of "disconnected state". The connectivity of default network in patients with AD and in patients with AD is weakened and broken, which provides a basis for the early diagnosis of aMCI and AD.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.16
本文編號：2237406
[Abstract]:Objective: to compare the difference of the default network structure of (PCC) related to posterior cingulate gyrus (PCC) between elderly patients with normal cognitive function and patients with AD by using resting BOLD-fMRI imaging, and to explore the application of resting BOLD-fMRI in MCI patients and AD patients. To provide imaging evidence for early diagnosis of aMCI and AD. Methods: ten patients with suspected aMCI were collected from Department of Neurology, first Hospital of Shanxi Medical University, including 4 males and 6 females, aged 63 to 78 years, with an average age of 69.3 years, 10 suspected AD patients, 6 males and 4 females. Ten healthy volunteers, 7 males and 3 females, with an average age of 60.75 years, were selected to match the sex, age and education level of AD and aMCI groups, with an average age of 67.8 years. Brain injury, cerebral hemorrhage, cerebral infarction, brain tumor, craniocerebral surgery and other nervous system diseases were excluded by routine cranial MRI. Resting BOLD-fMRI was performed in all subjects, and PCC was used as seed area to analyze the correlation between PCC and voxel based time series in other regions of the brain. The threshold value of activated brain area was set to the corrected P0.05, and the voxel range of activated brain region was 10. 05%. Results the age, sex and sex of the normal control group, MCI group and AD group, There was no significant difference in education level among the three groups. 2 the functional connections between normal control group and PCC included medial prefrontal area, bilateral hippocampus, dorsal thalamus, cuneiform lobe and precuneiform lobe. In the subparietal lobules, part of temporal lobes, bilateral cerebellar hemispheres and cerebellar vermis, the symmetry of the network structure was good, and the brain regions with functional connections with PCC showed similar to those in the normal control group, but the voxins in the activated brain regions were decreased. In the group of weak connectivity of network structure, the functional connectivity between AD and PCC included: bilateral medial prefrontal lobe, cuneiform and precuneiform lobe, inferior parietal lobule, part of temporal lobe, etc. The sites and areas of activation in AD group were significantly less than those in normal control group. No activation was found in the bilateral hippocampus, and the network structure was weakened and broken. Conclusion as a new method of MRI imaging, the study of brain morphology has been extended to the field of brain function imaging, which provides a better method for us to study brain function. The establishment of resting default network opens up a new way for us to diagnose AD. AD is considered to be a kind of "disconnected state". The connectivity of default network in patients with AD and in patients with AD is weakened and broken, which provides a basis for the early diagnosis of aMCI and AD.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.16
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