【摘要】：目的觀察老年輕度認(rèn)知功能障礙(MCI)患者與認(rèn)知功能正常(NC)老年人相比其血清25-羥維生素D[25(OH)D]水平的變化,并探討其臨床意義。方法符合入組標(biāo)準(zhǔn)的老年人共148例,采用協(xié)和版蒙特利爾認(rèn)知評(píng)估量表(Mo CA-P)評(píng)估其認(rèn)知功能。根據(jù)2003年國(guó)家神經(jīng)系統(tǒng)疾病和中風(fēng)研究所即NINDS及國(guó)際神經(jīng)科學(xué)協(xié)會(huì)即AIREN修訂的MCI診斷標(biāo)準(zhǔn),將入組的148例老年人分為NC組和MCI組,檢測(cè)比較兩組血清25(OH)D水平,分析血清25(OH)D水平與老年人MCI的相關(guān)性,用受試者工作特征曲線(ROC)評(píng)價(jià)血清25(OH)D水平對(duì)老年人MCI的預(yù)測(cè)價(jià)值。結(jié)果 MCI組(72例)、NC組(76例)血清25(OH)D水平分別為(33.43±15.04)nmol/L和(41.55±17.53)nmol/L,兩組相比,P0.01;25(OH)D缺乏者M(jìn)CI組64例(88.9%)、NC組51例(67.1%),兩組相比,P0.01。血清25(OH)D水平與Mo CA評(píng)分呈正相關(guān)(r=0.219,P0.01),25(OH)D缺乏者較25(OH)D非缺乏者發(fā)生MCI風(fēng)險(xiǎn)高(OR=3.816,P0.01)。血清25(OH)D水平降低對(duì)預(yù)測(cè)老年人MCI有一定價(jià)值[ROC的曲線下面積為0.637(95%CI為0.548~0.727),P0.01];血清25(OH)D水平聯(lián)合受教育年限、年齡對(duì)老年人MCI預(yù)測(cè)價(jià)值更高[ROC的曲線下面積為0.723(95%CI為0.642~0.804),P0.01]。結(jié)論老年MCI患者血清25(OH)D水平降低,血清25(OH)D水平降低與老年人MCI的發(fā)生相關(guān),25(OH)D缺乏老年人發(fā)生MCI風(fēng)險(xiǎn)高,檢測(cè)血清25(OH)D可能有助于對(duì)老年人MCI的預(yù)測(cè)。
[Abstract]:Objective to observe the changes of serum 25 hydroxyvitamin D [25 (OH) D] levels in elderly patients with mild cognitive impairment (MCI) compared with those with normal (NC), and to explore its clinical significance. Methods one hundred and forty-eight elderly patients who met the criteria were assessed with Concord Montreal Cognitive Assessment scale (Mo CA-P). According to the MCI diagnostic criteria revised by the National Institute of Neurologic Diseases and Stroke (NINDS) and the International Association of Neuroscience (AIREN) in 2003, 148 elderly patients were divided into NC group and MCI group. The serum 25 (OH) D levels were measured and compared between the two groups. The correlation between serum 25 (OH) D level and elderly MCI was analyzed, and the predictive value of serum 25 (OH) D level to elderly MCI was evaluated by (ROC). Results the levels of serum 25 (OH) D in 72 cases of MCI group (72 cases) and 76 cases of NC group were (33.43 鹵15.04) nmol/L and (41.55 鹵17.53) nmol/L, respectively, compared with those of MCI group (64 cases (88.9%), 51 cases (67.1%) of NC group and (41.55 鹵17.53) nmol/L, group respectively. There was a positive correlation between serum 25 (OH) D level and Mo CA score (r = 0.219 / P0.01). MCI risk (OR=3.816,P0.01) was higher in patients with 25 (OH) D deficiency than in non-deficient 25 (OH) D patients. The decrease of serum 25 (OH) D level had a certain value in predicting MCI in the elderly [the area under the ROC curve was 0.637 (95%CI = 0.548 鹵0.727) P0.01], and the age of 25 (OH) D level combined with education years was higher than that of age [the area under the ROC curve was 0.723 (95%CI = 0.642 鹵0.804) P0.01]. Conclusion the level of serum 25 (OH) D and the level of serum 25 (OH) D are lower in elderly patients with MCI and the risk of MCI is higher in the elderly with 25 (OH) D deficiency. The detection of serum 25 (OH) D may be helpful to predict MCI in the elderly.
【作者單位】： 北京大學(xué)人民醫(yī)院;
【基金】：北京市科技計(jì)劃項(xiàng)目(Z161100000116095)
【分類號(hào)】：R749.1

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