【摘要】：目的探討頸動脈斑塊與老年廣泛性腦萎縮并發(fā)認知功能障礙的相關(guān)性。方法選擇連云港市第二人民醫(yī)院就診或體檢發(fā)現(xiàn)的中、重度廣泛性腦萎縮的老年患者45例,按認知功能分為:正常組15例、輕度認知功能損害(MCI)組15例和阿爾茨海默病(AD)組15例。所有受試者均接受頸動脈斑塊檢測,并分析頸動脈斑塊與簡易智能狀態(tài)檢查量表(MMSE)評分的關(guān)系。結(jié)果與正常組比較,AD組和MCI組頸動脈內(nèi)膜中層厚度[(IMT)(2.37±0.28)mm和(2.35±0.13)mmvs(1.76±0.09)mm]及高回聲斑塊[(17.71±2.30)mm2和(18.96±2.12)mm2 vs(14.25±2.29)mm2]明顯增加(P0.05),MMSE評分[(5.80±3.53)分和(17.40±3.92)分vs(25.73±3.08)分]明顯降低(P0.05);與MCI組比較,AD組MMSE評分明顯降低(P0.05)。3組低回聲及混合回聲斑塊平均面積差異無統(tǒng)計學意義(P0.05)。線性回歸分析顯示,IMT與MMSE評分呈負相關(guān)(P=0.000)。結(jié)論腦萎縮伴IMT或高回聲斑塊平均面積增多的患者易發(fā)生認知功能損害,IMT越高認知功能越低;頸部超聲檢查可視為老年腦萎縮患者并發(fā)認知功能損害的隨訪指標之一。
[Abstract]:Objective to investigate the relationship between carotid plaque and cognitive impairment in elderly patients with generalized brain atrophy. Methods Forty-five elderly patients with moderate and severe extensive brain atrophy were selected from Lianyungang second people's Hospital. According to their cognitive function, 15 patients were divided into normal group and normal group. There were 15 cases of mild cognitive impairment in (MCI) group and 15 cases of Alzheimer's disease (AD) group. All subjects were examined for carotid plaque, and the relationship between carotid plaque and (MMSE) score was analyzed. Results the intima-media thickness of carotid artery [(IMT) (2.37 鹵0.28) mm and (2.35 鹵0.13) mmvs (1.76 鹵0.09) mm] and hyperechoic plaques [(17.71 鹵2.30) mm2 and (18.96 鹵2.12) mm2 vs (14.25 鹵2.29) mm2] in AD group and MCI group were significantly increased (P0.05) than those in control group [(5.80 鹵3.53) and (17.40 鹵3.92) vs (25.73 鹵3.08) mm], and the MMSE score in AD group was significantly lower than that in MCI group (P0.05). There was no significant difference in the mean area of hypoechoic plaque and mixed echo plaque between the two groups (P0.05). Linear regression analysis showed that there was a negative correlation between IMT and MMSE score (P0. 000). Conclusion patients with cerebral atrophy with IMT or hyperechoic plaque mean area increase are prone to cognitive impairment the higher the cognitive function the lower the cognitive function. Cervical ultrasonography can be regarded as one of the follow-up indicators of cognitive impairment in elderly patients with cerebral atrophy.
【作者單位】： 連云港市第二人民醫(yī)院老年醫(yī)學科;
【基金】：蚌埠醫(yī)學院科研項目(Byky1289NF)
【分類號】：R749.16

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