【摘要】：目的：應(yīng)用腦電圖及腦漲落圖技術(shù),分析網(wǎng)絡(luò)成癮青少年腦電圖和腦內(nèi)神經(jīng)遞質(zhì)功率的特點,探討網(wǎng)絡(luò)成癮青少年腦功能的改變。 方法：研究對象分為兩組：網(wǎng)絡(luò)成癮組和正常對照組。成癮組38例,為2008年12月至2012年1月期間就診于湖南省腦科醫(yī)院成癮科的成癮青少年,均符合Young制定的網(wǎng)絡(luò)成癮診斷標(biāo)準(zhǔn),年齡12-29歲,平均年齡20.53±4.45歲。對照組35例,為同期體檢結(jié)果正常的無網(wǎng)絡(luò)成癮青少年,年齡12～29歲,平均年齡20.23±4.32歲。兩組研究對象性別、年齡、受教育年限及接觸網(wǎng)絡(luò)年限均相匹配。網(wǎng)絡(luò)成癮組的成癮時間0.5～11年,平均4.46±2.29年。 采用中文網(wǎng)絡(luò)成癮量表修訂版,對兩組受試者進行網(wǎng)絡(luò)成癮程度評分。 記錄安靜、清醒、閉目狀態(tài)下的腦電圖,對所有受試者的圖形進行目測閱圖和功率值測定。采用SPSS17.0軟件對兩組受試者目測閱圖結(jié)果的異常率、異常部位、腦電異常程度和成癮年限的相關(guān)性以及功率值進行統(tǒng)計分析。 通過腦電超慢漲落圖技術(shù)得到兩組受試者的γ-氨基丁酸、谷氨酸、5-羥色胺、乙酰膽堿、去甲腎上腺素、多巴胺六種神經(jīng)遞質(zhì)的功率值,以及興奮抑制指數(shù)。統(tǒng)計分析兩組間六種神經(jīng)遞質(zhì)功率和興奮抑制指數(shù),并對差異有顯著性的指標(biāo)與中文網(wǎng)絡(luò)成癮量表修訂版評分進行相關(guān)性分析。 結(jié)果：中文網(wǎng)絡(luò)成癮量表修訂版評分統(tǒng)計分析結(jié)果：網(wǎng)絡(luò)成癮組與正常對照組比較,量表評分明顯增高,差異有統(tǒng)計學(xué)意義(P0.05)。 腦電圖檢查統(tǒng)計分析結(jié)果：1)成癮組與對照組在目測閱圖結(jié)果的比較：成癮組目測閱圖的異常率較對照組升高,病變部位主要是額區(qū),差異有統(tǒng)計學(xué)意義(P0.05)；成癮組的成癮年限與目測閱圖的異常度的相關(guān)分析中,P0.05,提示網(wǎng)絡(luò)成癮青少年的腦電圖異常度與成癮時間不相關(guān)。2)兩組腦電功率的比較結(jié)果：成癮組雙側(cè)額、顳較正常對照組慢波(δ、0波)的功率增高。 腦漲落圖統(tǒng)計分析結(jié)果：1)成癮組與對照組在腦漲落圖結(jié)果的比較：與對照組相比,成癮組的多巴胺功率、5-羥色胺功率和興奮抑制指數(shù)降低,差異有統(tǒng)計學(xué)意義(P0.05)。2)網(wǎng)絡(luò)成癮量表修訂版評分與神經(jīng)遞質(zhì)功率水平的相關(guān)性分析結(jié)果：網(wǎng)絡(luò)成癮量表修訂版評分與5-羥色胺功率值、多巴胺功率值以及興奮抑制指數(shù)均呈負相關(guān)(P0.05),相關(guān)系數(shù)分別為-0.323,-0.775,-0.252。 結(jié)論：1)腦電圖顯示網(wǎng)絡(luò)成癮青少年額、顳腦區(qū)腦功能處于抑制狀態(tài),抑制程度與成癮的時間不相關(guān)。腦興奮性降低是導(dǎo)致網(wǎng)絡(luò)成癮的可能原因。 2)腦漲落圖顯示網(wǎng)絡(luò)成癮青少年顱內(nèi)多巴胺、5-羥色胺功率降低,可能是大腦額、顳葉功能抑制的物質(zhì)基礎(chǔ)。
[Abstract]:Objective: to analyze the characteristics of EEG and the power of neurotransmitters in the brain of the adolescents with internet addiction by using EEG and fluctuation graph, and to explore the changes of brain function in adolescents with iad. Methods: the subjects were divided into two groups: Internet addiction group and normal control group. From December 2008 to January 2012, 38 patients in the addictive group were admitted to the Department of Addiction in the brain Hospital of Hunan Province. All of them were in accordance with the criteria for the diagnosis of Internet addiction established by Young. The average age was 20.53 鹵4.45 years old, aged 12-29 years. The control group (n = 35) was a non-internet addicted teenager with normal physical examination results. The average age was 20. 23 鹵4. 32 years with a age of 12 to 29 years. Gender, age, years of education and exposure to the Internet were matched equally between the two groups. The addiction time of iad group was 0.5 ~ 11 years (mean 4.46 鹵2.29 years). The Chinese Internet Addiction scale was used to evaluate the degree of iad in the two groups. Electroencephalogram (EEG) in quiet, awake and closed state was recorded, and the figures of all subjects were measured by visual reading chart and power value. SPSS17.0 software was used to analyze the abnormal rate, abnormal position, abnormal degree of EEG and addiction years and power value of the two groups of subjects. The power values of 緯 -aminobutyric acid, glutamate 5-hydroxytryptamine, acetylcholine, norepinephrine and dopamine neurotransmitters, as well as the excitatory inhibition index of the two groups were obtained by electroencephalogram. The power of six neurotransmitters and the excitation inhibition index were analyzed statistically and the correlation between the significantly different indexes and the revised score of the Chinese Internet Addiction scale was analyzed. Results: the scores of the revised version of the Chinese Internet Addiction scale were significantly higher in the iad group than in the normal control group (P0.05). The results of EEG statistical analysis showed that the abnormal rate of visual map in addiction group and control group was higher than that in control group, and the lesion location was mainly frontal area, the difference was statistically significant (P0.05). The correlation analysis of addictive years and abnormal degree of visual reading map in addiction group (P0.05, indicating that the abnormal degree of EEG of internet addicted adolescents is not related to addictive time (.2) the results of comparison of EEG power between two groups: the bilateral forehead of addiction group; The power of slow wave (未 0 wave) in temporal group was higher than that in normal control group. The results of brain fluctuation analysis showed that the dopamine power of addiction group was lower than that of control group, and the dopamine power and excitation inhibition index of addiction group were lower than that of control group, compared with the control group, the brain fluctuation analysis showed that the dopamine power and the excitatory inhibition index of the addiction group were lower than those of the control group. The difference was statistically significant (P0.05). The results of correlation analysis between the revised scale of iad and the level of neurotransmitter power were as follows: the revised score of iad and the value of 5-hydroxytryptamine power. There was a negative correlation between dopamine power and excitatory inhibition index (P0.05), the correlation coefficients were -0.323- 0.775U -0.252, respectively. Conclusion (1) EEG showed that the brain function in the brain of iad adolescents was in a state of inhibition, and the degree of inhibition was not related to the time of addiction. The decrease of brain excitability is the possible cause of iad. 2) the decrease of brain dopamine 5-hydroxytryptamine power may be the material basis for the inhibition of brain function in frontal and temporal lobes.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.99

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