【摘要】：目的應(yīng)用彌散張量成像(DTI)技術(shù)獲取全腦白質(zhì)各向異性(FA)值,研究首發(fā)兒童青少年精神分裂癥全腦白質(zhì)纖維是否受到損害,探討早發(fā)精神分裂癥的白質(zhì)異常與精神分裂癥的關(guān)聯(lián)性。方法入組符合DSM-Ⅳ診斷標(biāo)準(zhǔn)的首發(fā)精神分裂癥患者共19例(患者組),患者年齡均小于18歲,沒有使用過任何抗精神病藥物。同時選取19名年齡、性別相匹配的健康自愿者(對照組)。所有的患者和健康對照者都接受了DTI和結(jié)構(gòu)相的磁共振成像(MRI)掃描。檢測大腦各區(qū)域的FA值,分析患者組與健康對照組之間FA值的差異。結(jié)果患者組左額下回、左顳下回、左枕葉、右顳中回白質(zhì)FA值顯著低于健康對照組(P0.001)。結(jié)論首發(fā)兒童青少年精神分裂癥患者腦區(qū)存在廣泛的白質(zhì)損傷,提示白質(zhì)異�？赡芘c早發(fā)精神分裂的發(fā)病相關(guān)。
[Abstract]:Objective to obtain the anisotropic (FA) values of the white matter of the whole brain by using diffusion Zhang Liang imaging (DTI), and to study whether the white matter fibers of the whole brain were damaged in the first episode of schizophrenia in children and adolescents. To investigate the relationship between white matter abnormality and schizophrenia in early onset schizophrenia. Methods A total of 19 first-episode schizophrenia patients (patients group) who met the diagnostic criteria of DSM- 鈪，

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