【摘要】：目的調(diào)查兒童精神分裂癥患者神經(jīng)系統(tǒng)軟體征(neurological soft signs,NSS)的發(fā)生狀況,并探討其與精神分裂癥斷裂基因1(disrupted in schizophrenia 1,DISC1)rs4658971多態(tài)性的關(guān)系。方法收集兒童精神分裂癥患者146例為患者組,154名健康兒童為兒童對(duì)照組,以及160名健康成人為成人對(duì)照組。使用劍橋神經(jīng)科檢查軟體征測(cè)試分量表評(píng)估患者組及兒童對(duì)照組的NSS,采用PCR-RFLP技術(shù)檢測(cè)患者組及成人對(duì)照組DISC1 rs4658971多態(tài)性。結(jié)果患者組NSS中運(yùn)動(dòng)協(xié)調(diào)因子所有9項(xiàng)條目,以及左右皮膚書寫感測(cè)驗(yàn)、右側(cè)鏡像運(yùn)動(dòng)1、掃視時(shí)頭移動(dòng)、眼睛閃爍等條目的陽性率均高于兒童對(duì)照(均P0.05);NSS總分、運(yùn)動(dòng)協(xié)調(diào)分、感覺整合分、脫抑制分均高于兒童對(duì)照(均P0.05)。攜帶T等位基因的患者左右序列對(duì)指運(yùn)動(dòng)、左右拳手掌測(cè)驗(yàn)、左右皮膚書寫感測(cè)驗(yàn)、右側(cè)鏡像運(yùn)動(dòng)1、掃視時(shí)頭移動(dòng)、眼睛閃爍的陽性率,及NSS總分、運(yùn)動(dòng)協(xié)調(diào)分、感覺整合分、脫抑制分高于CC型患者(均P0.05)。患者組與成人對(duì)照之間DISC1 rs4658971基因型和等位基因頻率差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論兒童精神分裂癥患者較健康兒童有明顯的神經(jīng)系統(tǒng)軟體征。攜帶T等位基因的兒童精神分裂癥患者神經(jīng)系統(tǒng)軟體征更明顯。
[Abstract]:Objective to investigate the occurrence of nervous system soft sign (neurological soft) in children with schizophrenia, and to explore its association with the rs4658971 polymorphism of schizophrenia breakage gene 1 (disrupted in schizophrenia 1 (DISC1). Methods 146 children with schizophrenia were collected as control group and 154 healthy children as control group and 160 healthy adults as adult control group. The NSSs of the patient group and the control group were evaluated by Cambridge Neurology soft sign scale, and the DISC1 rs4658971 polymorphism was detected by PCR-RFLP technique in the patient group and the adult control group. Results the positive rates of all 9 items of motor coordination factor in NSS and the left and right skin writing sense test, right mirror movement 1, head movement during scanning and eye flicker were all higher than those in the control group (P0.05), the total score of NSS and motor coordination score were significantly higher than those in the control group (P0.05). The scores of sensory integration and deinhibition were higher than that of children (P0.05). The patients with T allele carried the right and left finger movement, left and right fist palm test, left and right skin writing feeling test, right mirror movement 1, the positive rate of head movement, eye flicker, and the total score of NSS, motor coordination score, sensory integration score. The decompression score was higher than that in CC type patients (P0.05). There was no significant difference in genotype and allele frequency of DISC1 rs4658971 between patients and adults (P0.05). Conclusion compared with healthy children, children with schizophrenia have obvious nervous system soft sign. Nervous system soft sign was more obvious in children with T allele.
【作者單位】： 新鄉(xiāng)醫(yī)學(xué)院第二附屬醫(yī)院;
【基金】：河南省重點(diǎn)科技攻關(guān)計(jì)劃項(xiàng)目(編號(hào):132102310446)
【分類號(hào)】：R749.3

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