【摘要】：[目的]認(rèn)知障礙是急性腦卒中后常見的并發(fā)癥之一。目前診斷認(rèn)知障礙，基本上是靠智能量表測定，缺少相應(yīng)的血清學(xué)指標(biāo)。本研究目的是通過探討卒中后認(rèn)知功能障礙的發(fā)生和嚴(yán)重程度與外周血清NSE和CRP濃度的相關(guān)性，把MMSE（簡易智能狀態(tài)量表）和血清學(xué)指標(biāo)相結(jié)合，提高臨床對卒中后認(rèn)知障礙診斷的準(zhǔn)確性，并分析其可能的原因，，為疾病早期預(yù)測和早期干預(yù)提供臨床依據(jù)。 [方法]依據(jù)MMSE量表評定將92例急性腦卒中患者分為卒中后認(rèn)知障礙組和卒中后無認(rèn)知障礙組，于發(fā)病后第3—5天清晨空腹采取血標(biāo)本，而后分別采用酶聯(lián)免疫吸附法和免疫比濁法測定血清NSE和CRP的濃度；其結(jié)果與20例正常對照組比較。 [結(jié)果]腦卒中患者血清NSE和CRP濃度均高于正常對照組，（P0.05）；卒中后認(rèn)知障礙組血清NSE和CRP濃度均高于卒中后無認(rèn)知障礙組，（P0.05），卒中后認(rèn)知障礙MMSE評分與血清NSE和CRP濃度呈負(fù)相關(guān)。 [結(jié)論]血清NSE和CRP濃度與卒中后認(rèn)知障礙關(guān)系密切，可反映腦卒中患者的認(rèn)知障礙程度，因此血清NSE和CRP可作為卒中后認(rèn)知障礙的生物學(xué)檢測指標(biāo)，檢測其濃度和量表評定相結(jié)合可以做為卒中后認(rèn)知障礙的輔助診斷指標(biāo)，為臨床上對卒中后認(rèn)知障礙的早發(fā)現(xiàn)、早治療提供依據(jù)。另外，認(rèn)知障礙的發(fā)生與腦卒中的部位及卒中面積都有一定的關(guān)系，但前者的影響可能更多，因本研究病例數(shù)量較少，因此還有待進一步研究。
[Abstract]:Objective: cognitive impairment is one of the common complications after acute stroke. At present, the diagnosis of cognitive impairment is based on intelligence scale, lack of corresponding serological indicators. The purpose of this study was to investigate the correlation between the occurrence and severity of cognitive dysfunction and the levels of NSE and CRP in peripheral blood of patients with stroke, and to combine MMSE with serological indexes. To improve the accuracy of clinical diagnosis of post-stroke cognitive disorder and analyze its possible causes, to provide clinical basis for early disease prediction and early intervention. [methods] according to the MMSE scale, 92 patients with acute stroke were divided into two groups: the post-stroke cognitive impairment group and the post-stroke no cognitive impairment group. Blood samples were taken on an empty stomach on the 3-5 days after the onset of stroke. The serum levels of NSE and CRP were determined by enzyme-linked immunosorbent assay (Elisa) and immunoturbidimetry respectively, and the results were compared with those of 20 normal controls. [results] the levels of serum NSE and CRP in stroke patients were higher than those in normal controls (P0.05), and the levels of NSE and CRP in post-stroke cognitive impairment group were higher than those in no cognitive impairment group after stroke (P0.05), the MMSE scores of post-stroke cognitive impairment were negatively correlated with serum NSE and CRP levels. [conclusion] Serum NSE and CRP levels are closely related to post-stroke cognitive impairment, which can reflect the degree of cognitive impairment in stroke patients. Therefore, serum NSE and CRP can be used as biological markers of post-stroke cognitive impairment. It can be used as an auxiliary diagnostic index of post-stroke cognitive impairment, which can provide evidence for early detection and early treatment of post-stroke cognitive impairment. In addition, the occurrence of cognitive impairment has a certain relationship with the location and area of stroke, but the former may have more influence, because the number of cases in this study is relatively small, so it needs further study.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.1

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