本文選題：復方海蛇膠囊 + 癡呆��； 參考：《中國老年學雜志》2017年19期

【摘要】：目的探討復方海蛇膠囊對老年癡呆患者血清甲狀腺激素、細胞炎癥因子和血凝指標水平的影響。方法選擇老年癡呆患者40例。入組受試患者采用常規(guī)治療,包括抗血小板、降脂藥物、降壓藥物及鈣拮抗劑等,在常規(guī)基礎(chǔ)上結(jié)合復方海蛇膠囊,連續(xù)治療2個月。比較治療前、治療后1個月及治療后2個月生活能力和認知功能改善、血清甲狀腺激素、細胞炎癥因子及血凝指標水平變化。結(jié)果治療后1個月和2個月老年癡呆生活量表(QOL-AD)和簡易智能狀態(tài)量表(MMSE)評分明顯高于治療前,且治療后2個月明顯高于治療后1個月(P0.05);治療后1個月和2個月三碘甲狀腺原氨酸(T3)、游離T3(FT3)、甲狀腺素(T4)、游離T4(FT4)、促甲狀腺激素(TSH)含量明顯高于治療前,且治療后2個月明顯高于治療后1個月(P0.05);治療后1個月和2個月白細胞介素(IL)-1和IL-6含量明顯低于治療前,且治療后2個月明顯低于治療后1個月(P0.05);治療后1個月和2個月纖維蛋白原(Fib)和D-二聚體(D-D)含量明顯低于治療前,且治療后2個月明顯低于治療后1個月(P0.05)。結(jié)論復方海蛇膠囊對老年癡呆患者可提高血清甲狀腺激素水平,改善細胞炎癥和血凝指標水平。
[Abstract]:Objective to study the effect of compound Hydra capsule on serum thyroid hormone, cytokine and blood coagulation in senile dementia patients. Methods 40 cases of senile dementia were selected. Patients in the group were treated with routine therapy, including antiplatelet, lipid-lowering drugs, hypotensive drugs and calcium antagonists, on the basis of routine therapy combined with compound Hydra capsule for 2 months. The changes of life ability and cognitive function, serum thyroid hormone, cytokines and blood coagulation were compared before, 1 month after treatment and 2 months after treatment. Results the scores of QOL-AD and MMSE at 1 and 2 months after treatment were significantly higher than those before treatment. The levels of triiodothyronine (T3), free T3 (FT3), thyroxine (T4), free T4 (FT4), thyrotropin (TSH) were significantly higher than those before treatment at 1 and 2 months after treatment (P0.05). The levels of interleukin (IL)-1 and IL-6 were significantly lower at 2 months after treatment than at 1 month after treatment (P0.05), and significantly lower than those before treatment at 1 month and 2 months after treatment. The levels of fibrinogen (Fib) and D-dimer (D-D) were significantly lower in 1 month and 2 months after treatment than before treatment and 2 months after treatment (P0.05), and the levels of fibrinogen (Fib) and D-dimer (D-D) in 2 months after treatment were significantly lower than those in 1 month after treatment (P0.05). Conclusion compound Haishen capsule can improve serum thyroid hormone level, cell inflammation and blood coagulation index in senile dementia patients.
【作者單位】： 永康市第三人民醫(yī)院精神科;浙江省立同德醫(yī)院精神科;
【基金】：永康市科技計劃項目(201339)
【分類號】：R749.16

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