本文選題：事件相關(guān)電位 + 注意缺陷多動障礙�。� 參考：《中國生物醫(yī)學(xué)工程學(xué)報》2014年04期

【摘要】：采用事件相關(guān)電位(ERPs)來研究注意缺陷多動障礙(ADHD)患兒在選擇注意任務(wù)下額區(qū)的神經(jīng)活動。實驗采用高密度的腦電采集儀來記錄受試在執(zhí)行改進的視覺持續(xù)性操作測試(Visual-CPT)范式下的ERPs,12名患兒(ADHD組)及13名健康兒童(對照組)參加本次試驗。在Go和No-go條件下,分別對兩組受試的行為學(xué)及ERPs進行分析和比較,并對結(jié)果進行雙樣本t檢驗。結(jié)果發(fā)現(xiàn),ADHD組在實驗過程中表現(xiàn)得較差,漏報率和錯誤率明顯增加,而且反應(yīng)時間明顯延長;無論是Go條件還是No-go條件,潛伏期未見顯著性差異,但是ADHD組相比對照組在額區(qū)表現(xiàn)出幅值顯著低的N2成分(P0.05);此外,ADHD組在No-go條件下具有幅值顯著高的P2成分(P0.05)。結(jié)果表明,ADHD患兒在認知功能執(zhí)行中產(chǎn)生障礙,而這種障礙可能與其額葉區(qū)域的ERPs波形幅值異常有關(guān)。
[Abstract]:Event-related potentials (ERPs) were used to study the neural activity in the frontal area under selective attention task in children with attention deficit hyperactivity disorder (ADHD). A high-density EEG apparatus was used to record 12 children (ADHD group) and 13 healthy children (control group) who performed the improved Visual Sustainability Operation Test (visual-CPT) paradigm. In the condition of go and No-go, the behavior and ERPs of the two groups were analyzed and compared, and the results were tested by double-sample t-test. The results showed that the ADHD group showed a poor performance in the course of the experiment, the rate of missing report and the error rate increased obviously, and the reaction time was prolonged obviously, and there was no significant difference in the latency between the go and No-go conditions, and there was no significant difference in the latency between the two groups. But compared with the control group, ADHD group showed significantly lower amplitude of N2 component (P0.05); in addition, ADHD group had significantly higher amplitude P2 component in No-go condition (P0.05). The results showed that children with ADHD had cognitive dysfunction, which might be related to the abnormal amplitude of ERPs in the frontal lobe.
【作者單位】： 華僑大學(xué)信息科學(xué)與工程學(xué)院;蘇州大學(xué)第三附屬醫(yī)院;常州市第一人民醫(yī)院腦科學(xué)研究中心;清華大學(xué)生物醫(yī)學(xué)工程系;
【基金】：國家自然科學(xué)基金(61203369)
【分類號】：R749.94

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