本文選題：共病性失眠 + 入睡困難��； 參考：《復(fù)旦大學(xué)》2013年碩士論文

【摘要】：研究目的 對(duì)比分析小劑量西酞普蘭和多塞平治療伴發(fā)焦慮癥的共病性失眠患者的有效劑量、療效、療程及安全性。 研究方法 采用隨機(jī)分組的方法,將78例伴發(fā)焦慮癥的共病性失眠患者分為西酞普蘭組(20mg/d)和多塞平組(12.5mg/d),兩組療程均為12周。兩名評(píng)定員于治療前及治療第4、8、12周末采用匹茲堡睡眠量指數(shù)表(PSQI,附表1)及漢密爾頓焦慮量表(HAMA,附表2)對(duì)受試者的睡眠質(zhì)量及焦慮情緒進(jìn)行測(cè)評(píng),記錄不良反應(yīng),并對(duì)數(shù)據(jù)進(jìn)行統(tǒng)計(jì)學(xué)分析。 研究結(jié)果 ①小劑量西酞普蘭和多塞平均可以明顯縮短伴發(fā)焦慮癥的共病性失眠患者的入睡時(shí)間,但多塞平組患者8周末及12周末入睡時(shí)間較西酞普蘭組改善更明顯(P=0.002,P0.001)；②小劑量西酞普蘭和多塞平均可以明顯改善伴發(fā)焦慮癥的共病性失眠患者的總睡眠時(shí)間、日間功能障礙、睡眠質(zhì)量,兩組差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)；③小劑量西酞普蘭組和多塞平組患者經(jīng)治療失眠狀況緩解的同時(shí),焦慮狀況也得到了緩解。④小劑量西酞普蘭組和多塞平組患者不良反應(yīng)差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.404)。 研究結(jié)論 小劑量西酞普蘭可明顯改善受試者的睡眠總體水平及焦慮狀況,可用于伴發(fā)焦慮癥的共病性失眠長(zhǎng)期治療藥物。小劑量多塞平十分適合做為伴發(fā)焦慮癥的共病性失眠患者改善失眠及焦慮癥狀的藥物,對(duì)于入睡困難明顯的共病性失眠患者有明顯療效。
[Abstract]:research objective
To compare and analyze the effective dose, efficacy, course of treatment and safety of low dose citalopram and doxepin in the treatment of comorbid insomnia patients with anxiety disorder.
research method
78 patients with common diseased insomnia associated with anxiety were divided into 78 cases of citalopram group (20mg/d) and doxepin group (12.5mg/d). The two groups were treated for 12 weeks. Before and after the treatment, two assessors adopted the Pittsburgh sleep index table (PSQI, Appendix 1) and Hamilton Anxiety Scale (HAMA, appendix 2). The sleep quality and anxiety of the subjects were assessed, and adverse reactions were recorded, and the data were statistically analyzed.
Research results
(1) small dose of citalopram and doxer could significantly shorten the time to fall asleep in the patients with concomitant anxiety disorder, but the sleep time of the patients in the 8 and 12 weekends of the doxepin group was better than that of the citalopram group (P=0.002, P0.001); and the average dose of citalopram and doxeb in the small dose of citalopram and doxeb could significantly improve the concomitant disease of the associated anxiety disorder. There was no significant difference in the total sleep time, daytime dysfunction and sleep quality of the insomniacs (P0.05). (3) the patients in the small dose of citalopram group and doxepin group were relieved at the same time with the treatment of insomnia. (4) there was no difference in the adverse reaction between the small dose of citalopram group and the doxepin group. Meaning (P=0.404).
research conclusion
Small dose of citalopram can significantly improve the overall level of sleep and anxiety in the subjects. It can be used for the long-term treatment of concomitant insomnia. Small dose doxepin is very suitable for improving insomnia and anxiety symptoms in patients with concomitant anxiety disorder. The patient has a significant effect.
【學(xué)位授予單位】：復(fù)旦大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R749.72

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 宋寶華;費(fèi)錦鋒;;西酞普蘭與多慮平治療抑郁癥的對(duì)比分析[J];四川精神衛(wèi)生;2008年02期

2 何彥霞;;焦慮癥患者的睡眠質(zhì)量及其相關(guān)影響因素的研究[J];中國(guó)民康醫(yī)學(xué);2010年16期

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本文編號(hào)：2052234