本文選題：酒依賴 + 執(zhí)行功能�。� 參考：《天津醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:探討男性酒依賴(alcohol dependence,AD)患者的事件相關(guān)電位P300異常與執(zhí)行功能異常的相關(guān)性,使用威斯康星卡片分類測驗了解AD患者的執(zhí)行功能。測定AD患者的事件相關(guān)電位P300異常與否,為AD執(zhí)行功能損害提供電生理依據(jù)。方法:收集30例男性AD患者為酒依賴組,30名健康男性為對照組,對兩組進行威斯康星卡片分類測驗(Wisconsin card sorting test,WCST)和事件相關(guān)電位P300(event-related potential P300,ERP-P300)測定,酒依賴患者WCST和ERP-P300均在戒斷癥狀消除后評估。結(jié)果:1.與健康對照組相比較,研究組患者的Rf、Re及Rpe顯著性升高,組間比較具有統(tǒng)計學(xué)差異(P0.05),而研究組患者的Cc、Cl顯著性降低,組間比較具有統(tǒng)計學(xué)差異(P0.05)。2.兩組ERP-P300波幅比較情況:研究組患者的N1、N2及P3均顯著性低于正常對照組,兩組之間比較具有統(tǒng)計學(xué)差異(P0.05);兩組之間ERP-P300潛伏期比較情況:研究組患者的N2、P3潛伏期顯著性長于正常組患者,兩組之間比較具有統(tǒng)計學(xué)差異(P0.05),而N1與對照組無顯著性差別,兩組之間比較無統(tǒng)計學(xué)差異(P0.05)。3.相關(guān)分析顯示,研究組患者的Cc與N1波幅呈正相關(guān)性(r=-0.879,P=0.0320.05),與N2波幅呈正相關(guān)性(r=-0.686,P=0.0270.05),與P3波幅呈正相關(guān)性(r=-0.753,P=0.0360.05),與N2潛伏期呈負(fù)相關(guān)性(r=0.366,P=0.6260.05),與P3潛伏期呈負(fù)相關(guān)性(r=0.345,P=0.3840.05);研究組患者的Cl與N1波幅呈正相關(guān)性(r=-0.776,P=0.0220.05),與N2波幅呈正相關(guān)性(r=0.399,P=0.0480.05),與P3波幅呈正相關(guān)性(r=0.498,P=0.0310.05),與N2潛伏期呈負(fù)相關(guān)性(r=0.732,P=0.7280.05),與P3潛伏期呈負(fù)相關(guān)性(r=0.936,P=0.2560.05);研究組患者的Rf與N1波幅呈負(fù)相關(guān)性(r=0.680,P=0.3720.05),與N2波幅呈負(fù)相關(guān)性(r=-0.987,P=0.5680.05),與P3波幅呈負(fù)相關(guān)性(r=0.259,P=0.4790.05),與N2潛伏期呈正相關(guān)性(r=0.456,P=0.0210.05),與P3潛伏期呈正相關(guān)性(r=-0.975,P=0.0080.05);研究組患者的Re與N1波幅呈負(fù)相關(guān)性(r=0.373,P=0.8990.05),與N2波幅呈負(fù)相關(guān)性(r=-0.674,P=0.1220.05),與P3波幅呈負(fù)相關(guān)性(r=0.449,P=0.2420.05),與N2潛伏期呈正相關(guān)性(r=0.926,P=0.0010.05),與P3潛伏期呈正相關(guān)性(r=0.475,P=0.0060.05);研究組患者的Rpe與N1波幅呈負(fù)相關(guān)性(r=-0.852,P=0.5220.05),與N2波幅呈負(fù)相關(guān)性(r=-0.673,P=0.4630.05),與P3波幅呈負(fù)相關(guān)性(r=0.576,P=0.2210.05),與N2潛伏期呈正相關(guān)性(r=0.858,P=0.0400.05),與P3潛伏期呈正相關(guān)性(r=0.774,P=0.0110.05);研究組患者的N1潛伏期與Cc、Rf、Cl、Re及Rpe之間均無統(tǒng)計學(xué)相關(guān)性(P0.05)。結(jié)論:酒依賴患者存在執(zhí)行功能障礙,表現(xiàn)為抽象概括、認(rèn)知轉(zhuǎn)移和反應(yīng)抑制能力下降及ERP-P300檢查譜系中多種結(jié)果的異常,主要體現(xiàn)在波幅及潛伏期的改變,ERP-P300的全面檢查分析,有助于全面地了解酒依賴患者執(zhí)行功能障礙的電生理特征。
[Abstract]:Objective: to investigate the correlation between P300 abnormality and executive dysfunction in male alcohol dependence patients, and to investigate the executive function of AD patients by Wisconsin card sorting test. In order to provide electrophysiological evidence for AD executive function damage, the abnormal event related potential (P300) of AD patients was measured. Methods: thirty male patients with AD were collected as alcohol dependent group and 30 healthy men as control group. Wisconsin card sorting test WCSTs and event-related potential P300-related potential P300ERP-P300 were measured in two groups. WCST and ERP-P 300 were evaluated after abstinence symptoms were eliminated. The result is 1: 1. Compared with the healthy control group, the RfN re and RPE in the study group were significantly higher than those in the control group, and there was a statistical difference between the two groups (P 0.05), while the CcnCl level in the study group was significantly lower than that in the control group (P 0.05 路2). Comparison of ERP-P300 amplitudes between the two groups: the N _ 1N _ 2 and P _ 3 of the patients in the study group were significantly lower than those in the normal control group. The latency of ERP-P300 in the study group was significantly longer than that in the normal group, and there was statistical difference between the two groups (P 0.05), but there was no significant difference between the N1 and the control group. There was no statistical difference between the two groups (P 0.05. 3). Correlation analysis shows that There was a positive correlation between the amplitude of cc and N1, a positive correlation between RC and N1 amplitude, a positive correlation with N2 amplitude, a positive correlation with P3 amplitude, a negative correlation with N2 latency, a negative correlation with P3 latency, and a negative correlation between Cl and wave amplitude. There was a positive correlation between RV and N2 amplitude, a positive correlation with N2 amplitude, a positive correlation with P3 amplitude, a negative correlation with N2 latency, a negative correlation with P3 latency, a negative correlation between rf and N1 amplitude, and a negative correlation between rf and N1 amplitude, a negative correlation with N2 latency, and a negative correlation with P3 latency. There was a negative correlation with P3 amplitude, a positive correlation with N2 latency, a positive correlation with P3 latency, a negative correlation between re and N1 amplitude, a negative correlation between re and N1 amplitude, a negative correlation with N2 latency, and a negative correlation with P3 latency. There was a positive correlation between RPE and N1 amplitude, a negative correlation between rpe and N1 amplitude, a negative correlation with N2 amplitude, a negative correlation with P3 amplitude, and a negative correlation between RPE and N1 amplitude, a negative correlation with N2 amplitude, a negative correlation with P3 amplitude, and a negative correlation with P3 amplitude, with a positive correlation between RPE and N1 amplitude, a negative correlation with N2 amplitude, and a negative correlation with P3 amplitude. There was a positive correlation between the N1 latency and the latency of P3, and there was no significant correlation between N1 latency and RFC, ClRe and RPE in the study group (P 0.05), and there was no significant correlation between N1 latency and P3 latency in the study group (P < 0 05), but there was no significant correlation between the N1 latency and the RfN ClRe and RPE in the study group (P < 0 05). Conclusion: there are executive dysfunction in patients with alcohol dependence, such as abstract generalization, decreased cognitive transfer and response inhibition and abnormal results in ERP-P300 pedigree, which are mainly reflected in the changes of amplitude and latency of ERP-P300 and the comprehensive examination and analysis of ERP-P300. It is helpful to understand the electrophysiological characteristics of executive dysfunction in patients with alcohol dependence.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R749.62

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