本文選題：雙相情感障礙 + 抑郁發(fā)作��； 參考：《南昌大學(xué)》2013年碩士論文

【摘要】：目的：探討阿立哌唑與喹硫平分別合并丙戊酸鈉治療雙相情感障礙抑郁發(fā)作的療效及安全性。方法：將56例符合DSM-IV雙相障礙抑郁發(fā)作診斷標(biāo)準(zhǔn)的患者隨機(jī)分為兩組。阿立哌唑組28例，予以阿立哌唑合并丙戊酸鈉治療；喹硫平組28例，予以喹硫平合并丙戊酸鈉治療，觀察8周。兩組分別于治療前、治療第1周末、2周末、4周末、6周末、8周末采用漢密爾頓抑郁量表（HAMD-17）、臨床大體印象量表（CGI）評定臨床療效。同時(shí)采用治療時(shí)出現(xiàn)的癥狀量表（TESS）進(jìn)行安全性評估。結(jié)果：治療結(jié)束時(shí)，兩組HAMD-17評分較入組時(shí)均顯著降低（p0.05）。治療8周末，臨床總體有效率，阿立哌唑組92.9%，喹硫平組96.4%，差異無顯著性（p0.05）。兩組不良反應(yīng)發(fā)生率均較低，，阿立哌唑組39.3%，喹硫平組32.1%，差異無顯著性（p0.05），且程度較輕。結(jié)論：阿立哌唑與喹硫平分別合并丙戊酸鈉對雙相障礙抑郁發(fā)作療效顯著，總體療效相當(dāng)，且副反應(yīng)輕，安全性高。
[Abstract]:Objective: to investigate the efficacy and safety of aripiprazole and quintiapine combined with sodium valproate in the treatment of bipolar depression. Methods: 56 patients who met the diagnostic criteria of DSM-IV bipolar disorder were randomly divided into two groups. Aripiprazole group (n = 28) was treated with aripiprazole combined with valproate sodium (n = 28) and quetiapine group (n = 28) with sodium valproate for 8 weeks. Before treatment, the two groups were treated with Hamilton Depression scale (Hamilton Depression scale) and CGI respectively at the 1st weekend, 2nd weekend, 4th weekend and 6th weekend, respectively, and CGI was used to evaluate the clinical efficacy. At the same time, the safety was evaluated by symptom scale (TESS). Results: at the end of treatment, HAMD-17 score of both groups was significantly lower than that of entering group. At the end of 8 weeks, the overall clinical effective rate was 92.9 in aripiprazole group and 96.4 in quintiapine group, with no significant difference (P 0.05). The incidence of adverse reactions was lower in the two groups, 39.3 in aripiprazole group and 32.1in quetiapine group. There was no significant difference between the two groups (p 0.05), and the degree was less than that of aripiprazole group. Conclusion: aripiprazole and quetiapine combined with sodium valproate are effective in the treatment of bipolar disorder depression.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R749.4

【引證文獻(xiàn)】

相關(guān)期刊論文 前1條

1 曹天忠;;阿立哌唑合并抗抑郁藥治療抑郁癥的臨床療效及安全性分析[J];中國醫(yī)藥指南;2016年22期

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