發(fā)布時間：2018-06-06 14:32

  本文選題：低阻抗意念導(dǎo)入療法(TIP技術(shù)) + 喜樂寧顆粒��； 參考：《北京中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的觀察低阻抗意念導(dǎo)入療法(TIP技術(shù))聯(lián)合喜樂寧顆粒治療肝郁脾虛型輕中度抑郁癥的臨床療效及安全性,為抑郁癥的臨床治療提供新的治療方法。方法將69例在中國中醫(yī)科學(xué)院廣安門醫(yī)院心理睡眠科就診的肝郁脾虛型輕中度抑郁癥患者隨機分為治療組與對照組,治療組采用TIP技術(shù)聯(lián)合喜樂寧顆粒治療,對照組用喜樂寧顆粒進(jìn)行治療,觀察周期為8周,喜樂寧顆粒每日1劑,TIP技術(shù)每周2次治療,每次40-50分鐘。療效指標(biāo):心理指標(biāo)為漢密爾頓抑郁量表(HAMD)、漢密爾頓焦慮量表(HAMA)、貝克抑郁量表(BDI)、中醫(yī)五態(tài)人格量表;安全性指標(biāo):肝腎功能、血尿常規(guī)、心電圖。結(jié)果治療組和對照組病例年齡、性別、文化程度、病程,以及各觀察指標(biāo)基線比較無顯著差異,P0.05,具有可比性。經(jīng)過8周治療,治療組總有效率為90%,對照組總有效率為74.20%,治療組優(yōu)于對照組,P0.05。1抑郁量表得分比較1.1組間比較通過獨立樣本t檢驗,兩組HAMD、HAMA、BDI評分在4周開始出現(xiàn)差異,P0.05,差異持續(xù)至治療8周,其中HAMA差異明顯,P0.01,治療組優(yōu)于對照組。對抑郁癥癥狀的治療,治療組更有優(yōu)勢。1.2組內(nèi)比較通過配對樣本t檢驗,治療4周、8周后,治療組HAMD、HAMA、BDI得分較治療前均有明顯差異,P0.01;治療4周后,對照組HAMD、HAMA、BDI得分較治療前無明顯差異,P0.05,治療8周后,對照組HAMD、HAMA、BDI得分較治療前有明顯差異,P0.05。兩組均有良好效果,且在治療時間上,治療組起效更快。2五態(tài)人格量表得分比較2.1組間比較通過獨立樣本t檢驗,兩組五態(tài)人格量表少陰、太陰因子評分在治療8周時出現(xiàn)差異,P0.05。2.2組內(nèi)比較通過配對樣本t檢驗,治療8周后,治療組五態(tài)人格量表少陰、太陰因子評分出現(xiàn)明顯差異,P0.05;對照組五態(tài)人格量表太陰因子評分出現(xiàn)明顯差異,P0.05。治療8周后,兩組治療對抑郁癥人格易感性均有影響,治療組作用更明顯。結(jié)論1.TIP技術(shù)聯(lián)合喜樂寧顆粒治療與單純喜樂寧顆粒治療均能明顯改善肝郁脾虛型輕中度抑郁癥患者的抑郁癥癥狀;2.TIP技術(shù)聯(lián)合喜樂寧顆粒治療起效更快,療效優(yōu)于單用喜樂寧顆粒;3.TIP技術(shù)聯(lián)合喜樂寧顆粒治療對抑郁癥中焦慮的改善優(yōu)于單用喜樂寧顆粒;4.TIP技術(shù)聯(lián)合喜樂寧顆粒通過改善抑郁癥患者的臨床癥狀,對五態(tài)人格量表中少陰、太陰兩個維度產(chǎn)生了一定影響,喜樂寧顆粒通過改善抑郁癥的臨床癥狀,對太陰這一維度產(chǎn)生了一定影響;5.TIP技術(shù)聯(lián)合喜樂寧顆粒臨床應(yīng)用無明顯副作用,安全性好。
[Abstract]:Objective to observe the clinical efficacy and safety of low impedance ideation therapy (tip) combined with Xilening granule in the treatment of mild and moderate depression with liver depression and spleen deficiency, and to provide a new method for the treatment of depression. Methods 69 patients with mild and moderate depression with liver depression and spleen deficiency were randomly divided into treatment group and control group. The treatment group was treated with TIP combined with Xilening granule. The control group was treated with Xilening granule for 8 weeks, and Xilening granule was treated twice a week for 40 to 50 minutes with 1 dose per day. Outcome indicators: Hamilton Depression scale (Hamd), Hamilton anxiety scale (Hamilton anxiety scale), Beck Depression scale (BDI), TCM Five-state Personality scale (TCM), Safety Index: liver and Kidney function, Blood and urine routine, ECG. Results there was no significant difference between the treatment group and the control group in age, sex, education level, course of disease and baseline of each observation index (P 0.05). After 8 weeks of treatment, the total effective rate of the treatment group was 90 and the total effective rate of the control group was 74.20. The treatment group was superior to the control group in comparing the scores of P0.05.1 depression scale and 1.1 groups. The difference between the two groups began to appear at 4 weeks after treatment (P 0.05), and the difference lasted until 8 weeks. The difference of HAMA was significant (P 0.01), which was better in the treatment group than in the control group. For the treatment of depressive symptoms, the treatment group had more advantages. The comparison between the treatment group and the control group showed that after 4 weeks and 8 weeks of treatment, the BDI score of the treatment group was significantly different from that of the pre-treatment group (P 0.01), and after 4 weeks of treatment, the BDI score of the treatment group was significantly different from that of the control group (P 0.01). There was no significant difference in BDI score between the control group and the control group (P 0.05). After 8 weeks of treatment, the BDI score of the control group was significantly different from that of the control group (P 0.05). Two groups have good effect, and in the treatment time, the treatment group takes effect more quickly .2 five-state personality scale score 2.1 comparison between groups through independent sample t-test, the two groups five-state personality scale less yin, After 8 weeks of treatment, there was a difference in the score of Taiyin factor in P0.05.2.2 group. After 8 weeks of treatment, the five-state personality scale of treatment group was less negative than that of P0.05.2.2 group. There was significant difference in the score of Taiyin factor (P 0.05) and the score of the five state personality scale (P 0.05) in the control group (P < 0.05). After 8 weeks of treatment, both groups had effects on personality susceptibility to depression, especially in the treatment group. Conclusion 1.TIP combined with Xilening granule and Xilonin granule alone can significantly improve the depression symptoms in patients with mild and moderate depression with liver depression and spleen deficiency. 2. The effect of 1.TIP combined with Xilening granule is faster. The curative effect was better than that of Xilening granule alone. 3. The improvement of anxiety in depression was better than that of Xilening granule combined with Xilening granule alone. 4. The clinical symptoms of depression patients were improved by the combination of Xilening granule and Xilening granule. It has a certain effect on the two dimensions of Shaoyin and Taiyin in the Five-state Personality scale. Xilening granule improves the clinical symptoms of depression. It has a certain effect on the dimension of Taiyin. 5. The clinical application of TIP combined with Xilening granule has no obvious side effects and good safety.
【學(xué)位授予單位】：北京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R749.4

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