本文選題：哌羅匹隆 + 利培酮　； 參考：《中國藥房》2017年24期

【摘要】：目的:系統(tǒng)評價哌羅匹隆對比利培酮治療精神分裂癥的療效與安全性,為臨床提供循證參考。方法:計算機檢索萬方數(shù)據(jù)庫、中文科技期刊數(shù)據(jù)庫、相關期刊論文、中國生物醫(yī)學文獻數(shù)據(jù)庫和PubMed,收集哌羅匹隆(試驗組)對比利培酮(對照組)治療精神分裂癥的臨床隨機對照試驗(RCT),提取資料并按照改良后的Jadad評分標準評價納入研究質(zhì)量后,采用Rev Man5.0統(tǒng)計軟件對各效應指標進行Meta分析。結果:共納入12項RCT,合計1 050例患者。Meta分析結果顯示,兩組患者痊愈率比較,差異無統(tǒng)計學意義[OR=0.99,95%CI(0.75,1.30),P=0.93];對照組患者錐體外系反應發(fā)生率[OR=0.63,95%CI(0.43,0.92),P=0.02]、泌乳素水平升高發(fā)生率[OR=0.23,95%CI(0.14,0.38),P0.001]和體質(zhì)量增加發(fā)生率[OR=0.23,95%CI(0.13,0.39),P0.001]顯著高于試驗組,差異均有統(tǒng)計學意義。結論:哌羅匹隆與利培酮治療精神分裂癥療效相當,但哌羅匹隆的安全性優(yōu)于利培酮。
[Abstract]:Objective: to evaluate the efficacy and safety of risperidone in the treatment of schizophrenia. Methods: Wanfang database, Chinese scientific and technological journal database and full text database of Chinese periodicals were searched by computer. The Chinese biomedical literature database and PubMedwere collected and compared with risperidone (control group) for the treatment of schizophrenia. The data were extracted and evaluated according to the improved Jadad score. Rev Man5.0 statistical software was used to analyze each effect index by Meta. Results: a total of 12 items of RCTs were included. The results of Meta-analysis showed that the recovery rate of the two groups was higher than that of the control group. There was no significant difference in the incidence of extrapyramidal reaction (OR0.6395), prolactin level increase (OR0.2395 CI0.140.38P0.001) and body mass increase (OR0.2395CI0.130.390.39P0.001) in the control group, and there was significant difference between the control group and the control group (P 0.001, P 0.001), and there was no significant difference between the control group and the control group in the incidence of extrapyramidal system reaction (OR0.6395CI0.390.39P0.001), the increase of prolactin level (OR0.23995 CI0.140.38P0.001) and the increase of body mass (0.2395% CI 0.130.390.39P0.001) were significantly higher in the control group than in the control group. Conclusion: piperopyrone and risperidone are effective in the treatment of schizophrenia, but the safety of piperopyrone is superior to risperidone.
【作者單位】： 重慶三峽中心醫(yī)院藥學部;川北醫(yī)學院藥學院;西南醫(yī)科大學藥學院;
【基金】：重慶市科技計劃項目(No.cstc2015shmszx120073) 重慶市萬州區(qū)科技計劃項目(No.201403055)
【分類號】：R749.3

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