本文選題：阿爾茨海默病 + 輕度認(rèn)知障礙��； 參考：《中風(fēng)與神經(jīng)疾病雜志》2014年04期

【摘要】：目的本研究通過光學(xué)相干斷層顯像儀(OCT)觀察阿爾茨海默病(AD)患者及輕度認(rèn)知障礙(MCI)患者視網(wǎng)膜纖維層(RNFL)厚度和黃斑厚度及容積與正常對(duì)照組是否存在異常。方法阿爾茨海默病患者25人,輕度認(rèn)知障礙患者26人,正常對(duì)照組20人。通過OCT對(duì)入組者RNFL及黃斑進(jìn)行觀察,以P0.05作為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果 AD組的RNFL厚度較對(duì)照組減小,除鼻側(cè)象限、12:00、2:00、3:00、4:00以外均達(dá)到統(tǒng)計(jì)學(xué)意義。AD組RNFL厚度較MCI組變薄,平均厚度、下象限、5:00、6:00、10:00和11:00的差異有統(tǒng)計(jì)學(xué)意義(P0.05)。與對(duì)照組相比時(shí),MCI患者的RNFL厚度在上象限、顳側(cè)象限及8:00、10:00、11:00明顯變薄且有統(tǒng)計(jì)學(xué)意義。AD組黃斑容積較對(duì)照組明顯減小,且P0.05。結(jié)論 AD和MCI患者出現(xiàn)視神經(jīng)視網(wǎng)膜退行性變,表現(xiàn)為視網(wǎng)膜纖維層厚度平均值及不同位點(diǎn)選擇性的變薄和黃斑容積的改變。
[Abstract]:Objective To observe whether the retinal fiber layer (RNFL) thickness and macular thickness and volume of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) were abnormal in the control group by optical coherence tomography (OCT). Methods 25 patients with Alzheimer's disease, 26 patients with mild cognitive impairment, and 20 normal controls. RNFL and macula were observed by OCT, and the difference of P0.05 was statistically significant. Results the thickness of RNFL in group AD was smaller than that of the control group. Except for the nasal quadrant, the thickness of RNFL in.AD group was thinner than that of the MCI group. The mean thickness, lower quadrant, 5:00,6:00,10:00 and 11:00 were statistically significant. P0.05. Compared with the control group, the RNFL thickness of the MCI patients was in the upper quadrant, the temporal quadrant and the 8:00,10:00,11:00 were significantly thinner and significantly decreased in.AD group than in the control group, and P0.05. concluded that the retina degeneration of the optic nerve was found in AD and MCI patients, showing the average value of the retinal thickness and the different loci. Selective thinning and changes in macular volume.

【作者單位】： 大連市友誼醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R749.1

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本文編號(hào)：1799945