本文選題：TAAR基因 + 基因多態(tài)性�。� 參考：《吉林大學學報(醫(yī)學版)》2014年03期

【摘要】：目的:探討人群中TAAR6基因多態(tài)性與精神分裂癥的關(guān)聯(lián),闡明TAAR6基因與精神分裂癥的關(guān)系。方法:通過計算機檢索PubMed、Cochrance、中國知網(wǎng)(CNKI)和萬方數(shù)據(jù)庫,檢索TAAR6基因多態(tài)性與精神分裂癥關(guān)聯(lián)的相關(guān)文獻。檢索時間為1994年1月—2013年5月公開發(fā)表的文獻。根據(jù)納入標準對相關(guān)文獻進行篩查,選出合適的文獻,提取文獻中的數(shù)據(jù)。以比值比(OR)和95%可信區(qū)間(95%CI)為效應指標。采用RevMan 5.1軟件對各項研究原始數(shù)據(jù)進行統(tǒng)計學分析,包括異質(zhì)性檢驗、合并效應量以及評估發(fā)表偏倚。結(jié)果:按照納入標準共有5篇文獻符合條件,共選取了5個位點進行Meta分析,rs8192625位點的等位基因合并OR=0.93,95%CI=0.81~1.07,P=0.32;基因型合并OR=0.88,95%CI=0.76~1.02,P=0.08。rs4305745等位基因合并OR=0.96,95%CI=0.90~1.03,P=0.29;基因型合并OR=1.03,95%CI=0.92~1.14,P=0.62。rs6903874位點的等位基因合并OR=0.95,95%CI=0.86~1.04,P=0.27;基因型合并OR=0.93,95%CI=0.84~1.04,P=0.20。rs6937506位點的等位基因合并OR=0.95,95%CI=0.86~1.04,P=0.27;基因型合并OR=0.93,95%CI=0.83~1.03,P=0.17。rs7772821位點的等位基因合并OR=0.96,95%CI=0.87~1.05,P=0.35;基因型合并OR=0.96,95%CI=0.86~1.07,P=0.47。結(jié)論:人群中TAAR6基因5個位點的等位基因和基因型多態(tài)性與精神分裂癥無關(guān)聯(lián),提示TAAR6基因多態(tài)性可能與精神分裂癥無關(guān)聯(lián)。
[Abstract]:Objective: to investigate the association between TAAR6 gene polymorphism and schizophrenia and to elucidate the relationship between TAAR6 gene and schizophrenia. Methods: a computer-based search of PubMedus Cochrance (CNKI) and Wanfang database was carried out to search the literature related to the association of TAAR6 gene polymorphism with schizophrenia. The search time is from January 1994 to May 2013. According to the inclusion criteria, the relevant documents are screened, the appropriate documents are selected, and the data from the literature are extracted. The ratio ratio (OR) and 95% CI (95% CI) were used as the effective indexes. The original data of each study were analyzed by RevMan 5.1 software, including heterogeneity test, combined effect quantity and evaluation bias. Results: according to the inclusion criteria, a total of 5 articles were eligible, 鍏遍，

本文編號：1796542