本文選題：腦卒中后抑郁 + 血清同型半胱氨酸　； 參考：《重慶醫(yī)學(xué)》2016年26期

【摘要】：目的分析腦卒中后抑郁(PSD)患者血清同型半胱氨酸水平與抑郁的相關(guān)性。方法以2014年1月至2015年7月,該中心神經(jīng)內(nèi)科收治的腦卒中存活患者作為研究對(duì)象,卒中后2周,采用漢密爾頓抑郁量表(HAMD-24)評(píng)價(jià)患者抑郁水平,≥17分為PSD組,17分為對(duì)照組,同時(shí)測(cè)定血清總膽固醇(TC)、高敏感C反應(yīng)蛋白(hs-CRP)、同型半胱氨酸(Hcy)、日常生活能力(ADL)等指標(biāo),隨訪至第90天,再次對(duì)兩組隨訪患者檢測(cè)相關(guān)指標(biāo)。以SPSS18.0軟件包進(jìn)行統(tǒng)計(jì)學(xué)處理。結(jié)果 PSD組TC、hs-CRP、Hcy高于對(duì)照組,ADL低于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);Hcy(r=18.153,P=0.000)、卒中量表(NIHSS,r=0.414,P=0.000)與HAMD-24評(píng)分具有相關(guān)性,PSD組患者Hcy與NIHSS、ADL存在顯著相關(guān)性;90d后,213例患者,獲得隨訪162例,其中,PSD組者42例,血清Hcy(15.3±3.2)mmol/L,對(duì)照組120例,血清Hcy(15.0±2.5)mmol/L,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論腦卒中患者發(fā)生PSD風(fēng)險(xiǎn)與血清Hcy水平顯著相關(guān)。
[Abstract]:Objective to analyze the correlation between serum homocysteine level and depression in patients with post-stroke depression (PSD). Methods from January 2014 to July 2015, survivors of stroke treated in the Department of Neurology of the Center were selected as study subjects. Two weeks after stroke, the depression level was evaluated by Hamilton Depression scale (HAMD-24), and 鈮，

本文編號(hào)：1782485