本文選題：強迫癥 + 錯誤監(jiān)測　； 參考：《安徽醫(yī)科大學》2012年碩士論文

【摘要】：目的探討強迫癥（obsessive-compulsive disorder, OCD）患者錯誤監(jiān)測功能有無損害以及錯誤監(jiān)測功能損害與注意網(wǎng)絡(luò)的相關(guān)性。 方法對確診的53例OCD患者進行錯誤監(jiān)測任務(wù)和注意網(wǎng)絡(luò)測定(AttentionNetwork Test， ANT)，并與36名正常組的實驗結(jié)果相比較。 結(jié)果在錯誤監(jiān)測任務(wù)中，OCD患者與正常對照組在全對（FC）、不確定、脫失數(shù)目、選擇反應(yīng)時以及總反應(yīng)時中有統(tǒng)計學差異(t=2.080，P=0.040；t=-2.015，P=0.047；t=-3.948，P=0.000；t=-3.489，P=0.001；t=-3.388，P=0.001）；OCD組中服藥組與未服藥組在選擇反應(yīng)時、評估反應(yīng)時和總反應(yīng)時存在顯著的統(tǒng)計學差異(t=2.275，P=0.029；t=2.367，P=0.022；t=3.002，P=0.004)。在注意網(wǎng)絡(luò)功能測驗中，OCD組與正常組在注意的警覺網(wǎng)絡(luò)的反應(yīng)時(RT)差異具有統(tǒng)計學意義（t=2.448，P=0.017）；錯誤監(jiān)測功能的損害與注意網(wǎng)絡(luò)功能有相關(guān)性。 OCD組中服藥組與未服藥組在選擇反應(yīng)時、評估反應(yīng)時和總反應(yīng)時存在顯著的統(tǒng)計學差異(t=2.275，P=0.029；t=2.367，P=0.022；t=3.002，P=0.004).相關(guān)性分析中，病程長短與錯誤監(jiān)測功能無顯著相關(guān)性，而PI-WSUR總分、不確定數(shù)、脫失數(shù)與錯誤監(jiān)測功能有著不同程度的相關(guān)性。 結(jié)論OCD患者錯誤監(jiān)測功能存在損害，這可能與注意網(wǎng)絡(luò)的損害有關(guān)，，因為它們之間存在共同的調(diào)控腦區(qū)前扣帶回皮層異常。SSRIs類藥物對OCD患者錯誤監(jiān)測功能無明顯的影響，但可能會使OCD患者的反應(yīng)抑制能力下降。
[Abstract]:Objective to investigate whether the wrong monitoring function of obsessive-compulsive disorder (OCD) patients is impaired and the relationship between the damage of error monitoring function and attention network.Methods 53 patients with OCD were examined by error monitoring task and attention network test, and the results were compared with those of 36 normal subjects.Results there were significant differences between the OCD patients and the normal control group in terms of FCU, uncertainty, number of loss, selected reaction time and total reaction time. There were significant differences in the selected reaction time and the total reaction time between the OCD patients and the normal control group. There was a significant difference between the two groups in the selected reaction time.There was significant statistical difference between the assessment time of reaction and the time of total reaction.In the attention network function test, there was significant difference between the OCD group and the normal group in the response time (RTT) of the attention alert network, and there was a correlation between the damage of the error monitoring function and the attention network function.In the OCD group, there was a significant difference between the response time and the total reaction time in the selective reaction between the drug group and the control group. There was a significant difference in the response time and the total reaction time between the two groups. There was a significant difference in the response time between the two groups. There was a significant difference between the two groups in the response time and the total reaction time. There was a significant difference in the response time between the two groups.In the correlation analysis, there was no significant correlation between the duration of the disease and the function of error monitoring, while the total score of PI-WSUR, the number of uncertainties, the number of loss and the function of error monitoring were correlated to different degrees.Conclusion the wrong monitoring function of OCD patients is impaired, which may be related to the damage of attention network, because there is a common regulation of the cortical abnormalities in the anterior cingulate cortex of the cerebral area between them. SSRIs have no obvious effect on the error monitoring function of OCD patients.However, it may decrease the ability of response inhibition in patients with OCD.
【學位授予單位】：安徽醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R749.7

【參考文獻】

相關(guān)期刊論文 前3條

1 劉春雷;張慶林;;錯誤加工的神經(jīng)機制[J];心理科學進展;2009年02期

2 龐礴;朱春燕;汪凱;張蕾;楊平;馬季;;PI-WSUR量表在中國大學生人群中的修訂[J];中國臨床心理學雜志;2009年02期

3 張一，孟凡強，崔玉華，甘向東，郭偉;修改耶魯—布朗強迫量表的臨床信度和效度研究[J];中國心理衛(wèi)生雜志;1996年05期

本文編號：1759905