本文選題：D-半乳糖　切入點(diǎn)：學(xué)習(xí)記憶　出處：《中國老年學(xué)雜志》2017年22期

【摘要】：目的探討超低頻電磁場處理水(簡稱頻譜水)對D-半乳糖誘致大鼠學(xué)習(xí)記憶障礙模型大鼠學(xué)習(xí)記憶的改善作用及其可能機(jī)制。方法 60只SD大鼠隨機(jī)分為5組,即正常對照組、模型組(D-半乳糖150 mg·kg~(-1)·d~(-1))、石杉堿甲組(0.031 mg·kg~(-1)·d~(-1))、紅外頻譜照射組和頻譜水組,每組12只。正常組腹腔注射等體積生理鹽水,其余各組大鼠均腹腔注射D-半乳糖6 w誘致學(xué)習(xí)記憶障礙,同時各組分別灌胃(或飲用)相應(yīng)受試物或紅外頻譜照射,采用穿梭和水迷宮法測試小鼠學(xué)習(xí)記憶能力,并測定血清、腦組織及海馬體組織的超氧化物歧化酶(SOD)、還原型谷胱甘肽(GSH-Px)的活力和丙二醛(MDA)、糖基化終末產(chǎn)物(AGEs)含量的變化。結(jié)果紅外頻譜照射和頻譜水均可改善模型小鼠的學(xué)習(xí)記憶能力,并提高血清和海馬組織SOD、GSH-Px的活力(P0.05),降低MDA、AGEs含量(P0.05)。結(jié)論紅外頻譜照射對D-半乳糖誘致大鼠學(xué)習(xí)記憶障礙模型有明顯的改善學(xué)習(xí)記憶作用,頻譜水對該模型的學(xué)習(xí)記憶有一定的改善作用,其機(jī)制可能與提高機(jī)體和大腦(尤其是海馬組織)的抗氧化能力有關(guān)。
[Abstract]:Objective to investigate the effect and possible mechanism of ultra-low frequency electromagnetic field (ultralow frequency) water treatment on learning and memory impairment induced by D-galactose in rats with learning and memory impairment.Methods Sixty Sprague-Dawley rats were randomly divided into 5 groups: normal control group, model group with 150 mg / kg galactose), Huperzine A group with 0.031 mg 路kg ~ (-1) 路d ~ (-1) ~ (-1), infrared spectrum irradiation group and frequency spectrum water group with 12 rats in each group.Rats in the other groups were injected intraperitoneally with Dgalactose for 6 weeks to induce learning and memory impairment. At the same time, the rats in each group were given intragastric administration (or drinking) of corresponding test material or infrared spectrum irradiation, and the other rats were injected intraperitoneally with Dgalactose for 6 weeks to induce learning and memory impairment.The learning and memory abilities of mice were measured by shuttle and water maze method. The activity of superoxide dismutase (SODX), reduced glutathione (GSH-Px) and the content of malondialdehyde (MDA) and glycosylation end product (AGEs) in serum, brain and hippocampus were measured.Results Infrared spectrum irradiation and spectral water could improve the learning and memory ability of the model mice, increase the activity of GSH-Px in serum and hippocampus, and decrease the content of MDA-AGEs.Conclusion Infrared spectrum irradiation can obviously improve the learning and memory of rats induced by D-galactose, and spectral water can improve the learning and memory of the model to some extent.The mechanism may be related to the enhancement of antioxidant capacity of the body and brain (especially hippocampus).
【作者單位】： 暨南大學(xué)藥學(xué)院;廣東駿豐頻譜股份有限公司;
【基金】：廣東駿豐頻譜股份有限公司產(chǎn)學(xué)研項目(JF2016-06)
【分類號】：R-332;R749.1

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