本文選題：非典型抗精神病藥　切入點(diǎn)：利培酮　出處：《大連醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的：了解非典型抗精神病藥物利培酮對(duì)男性精神分裂癥患者骨密度的影響。 方法：采用《測(cè)量骨密度影響因素調(diào)查問卷》對(duì)60例男性精神分裂癥患者(研究組)以及60例男性健康體檢人群(對(duì)照組)的一般情況進(jìn)行調(diào)查，收集可能影響骨密度的因素。兩組人群在年齡分布上無差異，研究組人群利培酮服藥史(x±s，年)4.412±2.554，病史(x±s，年)5.396±2.826。應(yīng)用雙能X線骨密度測(cè)量?jī)x對(duì)兩組人群進(jìn)行骨密度測(cè)定，采用雙變量相關(guān)分析研究精神分裂癥患者骨密度與各因素的相關(guān)性，，采用多因素逐步回歸方法分析各因素對(duì)骨密度的影響。 結(jié)果：兩組人群在體重指數(shù)、吸煙程度、飲用牛奶以及運(yùn)動(dòng)上存在差異(P＜0.05)。兩組骨密度值存在顯著差異(p=0.000)，研究組骨密度值明顯低于對(duì)照組。利培酮服藥史(r=-0.811, p=0.000)、病史(r=-0.812, p=0.000)、年齡(r=-0.289, p=0.027)、吸煙程度(r=-0.275, p=0.035)與研究組人群骨密度呈現(xiàn)負(fù)相關(guān)，運(yùn)動(dòng)(r=0.261,p=0.045)與骨密度呈現(xiàn)正相關(guān)。多因素逐步回歸分析顯示利培酮服藥史對(duì)骨密度影響最大，依次為年齡、運(yùn)動(dòng)，其中利培酮服藥史(β=-0.712, p=0.000)與年齡(β=-0.377,p=0.000)對(duì)骨密度呈現(xiàn)負(fù)性作用，運(yùn)動(dòng)(β=0.109, p=0.096)對(duì)骨密度存在正性作用。 結(jié)論：精神分裂癥患者骨密度值與健康人群相比顯著降低，骨密度值降低程度與骨質(zhì)疏松癥罹患人數(shù)均較健康人群高。其中藥物史是影響精神分裂癥患者骨密度的顯著因素，長(zhǎng)期服用利培酮可以導(dǎo)致患者骨密度值的降低，同時(shí)隨著年齡的增長(zhǎng)也可以增加患者骨量流失的風(fēng)險(xiǎn)。在選擇用藥上要慎重，尤其對(duì)于老年患者及病史較長(zhǎng)的患者，要注意預(yù)防由藥物引發(fā)的骨密度損傷的風(fēng)險(xiǎn)。
[Abstract]:Objective: to investigate the effect of atypical antipsychotic risperidone on bone mineral density (BMD) in male schizophrenic patients.Methods: the general situation of 60 male schizophrenic patients (study group) and 60 male healthy people (control group) were investigated by questionnaire on the influencing factors of bone mineral density (BMD), and the possible factors affecting BMD were collected.There was no difference in age distribution between the two groups. In the study group, the history of risperidone administration was x 鹵s, the history of risperidone was 4.412 鹵2.554, the history of disease was x 鹵s, and the age of risperidone was 5.396 鹵2.826.Dual energy X-ray absorptiometry was used to measure bone mineral density (BMD) in the two groups. The correlation between BMD and various factors in schizophrenia patients was studied by bivariate correlation analysis.Multivariate stepwise regression method was used to analyze the influence of various factors on bone mineral density (BMD).Results: there were significant differences in body mass index, smoking degree, milk consumption and exercise between the two groups (P < 0.05).There was significant difference in BMD between the two groups, and the BMD in the study group was significantly lower than that in the control group.The history of risperidone administration was negatively correlated with bone mineral density (BMD) of the study group (r = 0.261, P = 0.045), while the history of risperidone was r = -0.811, p = 0.000, r = 0.812, P = 0.000, age = r = 0.289, p = 0.027, smoking degree = r = 0.275, p = 0.035).Multivariate stepwise regression analysis showed that risperidone medication history had the greatest influence on BMD, followed by age and exercise. Among them, Risperidone medication history (尾 -0.712, p0. 000) and age (尾 -0. 377p0. 000) had negative effects on BMD, while exercise (尾 -0.109, p0. 096) had a positive effect on BMD.Conclusion: bone mineral density (BMD) of schizophrenic patients was significantly lower than that of healthy subjects, and the degree of BMD decrease and the number of osteoporosis patients were higher than that of healthy people.Drug history is a significant factor affecting bone mineral density in schizophrenic patients. Taking risperidone for a long time can lead to the decrease of bone mineral density and increase the risk of bone loss with age.We should be careful in the choice of medication, especially for the elderly patients and patients with a long history, we should pay attention to the prevention of drug-induced BMD injury risk.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R749.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前9條

1 李繼斌;骨量影響因素研究進(jìn)展[J];國(guó)外醫(yī)學(xué)(衛(wèi)生學(xué)分冊(cè));2000年04期

2 張剛;人體骨密度的影響因素[J];國(guó)外醫(yī)學(xué)(衛(wèi)生學(xué)分冊(cè));2004年03期

3 劉慧玲;袁春;包玲;;武漢市3220例40歲以下女性骨密度影響因素調(diào)查分析[J];中國(guó)全科醫(yī)學(xué);2011年02期

4 劉濤,張昊,杜寧;男性骨質(zhì)疏松癥研究概況[J];實(shí)用中西醫(yī)結(jié)合臨床;2003年01期

5 李旭鴻,侯曼,仰紅慧;骨密度的測(cè)定方法及影響因素[J];天津體育學(xué)院學(xué)報(bào);2005年03期

6 張硯華;楊乃龍;;男性骨密度的影響因素分析[J];疑難病雜志;2007年11期

7 溫孝恒;骨密度的測(cè)定方法[J];中國(guó)骨質(zhì)疏松雜志;1998年01期

8 何耀華,邱貴興;骨質(zhì)疏松診斷與骨密度測(cè)量[J];中國(guó)骨質(zhì)疏松雜志;1998年02期

9 孫建琴;維生素D與骨質(zhì)疏松及其骨折的防治研究[J];中國(guó)骨質(zhì)疏松雜志;1998年04期

本文編號(hào)：1717841