發(fā)布時(shí)間：2018-03-23 01:09

  本文選題：精神分裂癥　切入點(diǎn)：代謝綜合征　出處：《中南大學(xué)》2012年碩士論文　論文類型：學(xué)位論文

【摘要】：目的： 1.評(píng)估首發(fā)未服藥的精神分裂癥患者和正常對(duì)照的各項(xiàng)代謝綜合征相關(guān)指標(biāo),并比較二者間是否存在差異； 2.探討瘦素基因啟動(dòng)子區(qū)2548G/A及5-HTR2C基因759C/T兩個(gè)位點(diǎn)的多態(tài)性在首發(fā)精神分裂癥和正常對(duì)照之間是否存在差異,以及是否與代謝綜合征有關(guān)。 方法： 1.臨床研究部分：共入組首發(fā)未服藥的精神分裂癥患者100例,正常對(duì)照組118例。測(cè)量受試者的以下指標(biāo)：血壓、腰圍、臀圍、身高、血糖、體重、血脂、OGTT2h血糖、空腹胰島素；計(jì)算體質(zhì)量(BMI)、腰臀比(WHR)及胰島素抵抗指數(shù)(IRI)。 2.基因多態(tài)性研究部分：采用基質(zhì)輔助激光解吸/電離飛行時(shí)間質(zhì)譜(MALDI-TOFMS)方法,對(duì)精神分裂癥患者137例,正常對(duì)照組165例進(jìn)行2548G/A及759C/T兩個(gè)位點(diǎn)進(jìn)行基因分析。 結(jié)果： 1.首發(fā)未服藥的精神分裂癥患者組代謝綜合征的發(fā)生率為6%,顯著高于對(duì)照組的0.83%。 2.首發(fā)患者組的空腹血糖受損(IFG)、糖耐量降低(IGT)、糖尿病(DM)、糖代謝異常的發(fā)病率分別為4%、11%、7%、22%,顯著高于對(duì)照組(分別為0%、2.54%、0%、2.54%)。首發(fā)患者組的空腹血糖(4.75±0.74)、糖負(fù)荷后2小時(shí)血糖(6.50±1.79)、IRI(1.86±2.359)均顯著高于對(duì)照組(4.18±0.55,4.98±1.31,1.25±0.784)。 3.首發(fā)患者組的高密度脂蛋白(HDL-C)(1.31±0.32)顯著低于對(duì)照組(1.50土0.30)。 4.瘦素基因啟動(dòng)子區(qū)2548G/A及5-HTR2C基因759C/T兩個(gè)位點(diǎn)的基因型及等位基因頻率在兩組間無差異,且不同基因型間的糖、脂代謝指標(biāo)亦無顯著性差異。 結(jié)論： 1.首發(fā)未服藥的精神分裂癥中代謝綜合征發(fā)生率增高,二者之間可能存在共病的傾向。 2.首發(fā)未服藥的精神分裂癥患者中存在糖代謝的異常和HDL-C的降低。 3.未能證實(shí)瘦素基因和5-HT2C基因可能是精神分裂癥的易感基因；瘦素基因-2548G/A位點(diǎn)和5-HT2C基因-759C/T可能對(duì)糖脂代謝無影響。
[Abstract]:Objective:. 1. To evaluate the related indexes of metabolic syndrome between the first-episode patients with schizophrenia and the normal controls, and to compare whether there are differences between the two groups. 2. To investigate whether the polymorphism of 2548G/A and 5-HTR2C 759C/T in leptin promoter region is different between first-episode schizophrenia and normal control, and whether it is related to metabolic syndrome. Methods:. 1. Clinical study: 100 patients with schizophrenia and 118 normal controls were enrolled in the study. The following parameters were measured: blood pressure, waist circumference, hip circumference, height, blood glucose, weight, blood lipids, OGTT 2h blood glucose, fasting insulin; The body mass, waist to hip ratio (WHR) and insulin resistance index (IRI) were calculated. 2. Gene polymorphisms were studied by matrix assisted laser desorption / ionization time of flight mass spectrometry (MALDI-TOFMS) in 137 patients with schizophrenia and 165 normal controls. The 2548G/A and 759C/T loci were analyzed. Results:. 1. The incidence of metabolic syndrome in schizophrenic group was significantly higher than that in control group. 2. The incidence of impaired fasting blood glucose (IFG), impaired glucose tolerance (IGT), diabetes mellitus (DMN), and abnormal glucose metabolism in the first patient group were 41111 and 77.22%, respectively, which were significantly higher than those in the control group (0 ~ 2.54). The fasting blood glucose of the first patient group was 4.75 鹵0.74, and the blood glucose of 2 hours after glucose load was 6.50 鹵1.79 IRI _ (1.86 鹵2.359). It was significantly higher than that in the control group (4.18 鹵0.55U, 4.98 鹵1.31g, 1.25 鹵0.784). 3. The HDL-C of the first-episode group was significantly lower than that of the control group (1.50 鹵0.32 鹵1.31 鹵0.32). 4. The genotype and allele frequencies of 2548G/A and 5-HTR2C 759C/T in leptin promoter region were not different between the two groups, and there was no significant difference in glucose and lipid metabolism between the two groups. Conclusion:. 1. The incidence of metabolic syndrome in first-episode schizophrenia was increased, and there may be a tendency to co-develop between the two. 2. Abnormal glucose metabolism and decreased HDL-C were found in patients with schizophrenia. 3. Leptin gene and 5-HT2C gene may be susceptible to schizophrenia, but leptin gene -2548 G / A locus and 5-HT2C gene -759C / T may have no effect on glucose and lipid metabolism.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R749.3

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本文編號(hào)：1651205