本文選題：5-HTTLPR　切入點(diǎn)：抑郁癥狀　出處：《中南大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：目的(1)檢驗(yàn)5-羥色胺轉(zhuǎn)運(yùn)體基因啟動(dòng)子區(qū)域連鎖多態(tài)性(5-HTTLPR)對(duì)青少年抑郁癥狀的影響；(2)檢驗(yàn)5-HTTLPR與應(yīng)激性生活事件的交互效應(yīng)對(duì)抑郁癥狀的預(yù)測(cè)作用。 方法隨機(jī)抽取湖南省長(zhǎng)沙市某所高中的252名高一年級(jí)學(xué)生,并進(jìn)行為期2年共9次的追蹤研究。初次測(cè)評(píng)時(shí),分別用流調(diào)中心用抑郁量表(Center for Epidemiological Studies Depression Scale, CES-D)和青少年生活事件問(wèn)卷(Adolescent Life Events Questionnaire, ALEQ)評(píng)估被試的抑郁癥狀和生活事件,并抽取5mL靜脈血以提取DNA和鑒定5-HTTLPR基因型。初測(cè)后的2年中,每隔3個(gè)月對(duì)所有被試的抑郁癥狀和生活事件進(jìn)行追蹤評(píng)估,共8次追蹤。運(yùn)用多層線性模型(Hierarchical Linear Model, HLM)對(duì)收集的數(shù)據(jù)進(jìn)行統(tǒng)計(jì)分析。 結(jié)果多層線性模型分析顯示：(1)生活事件對(duì)男性和女性的抑郁癥狀均有顯著預(yù)測(cè)作用(男性：β=0.14,p0.0001；女性：β=0.13,p0.0001);(2)5-HTTLPR對(duì)男性和女性的抑郁癥狀的預(yù)測(cè)作用均無(wú)主效應(yīng)(男性：β=0.21,p0.05；女性：β=1.16,p0.05)；(3)女性樣本中,5-HTTLPR與生活事件交互作用顯著(β=0.08,p0.0001),攜帶S等位基因型的個(gè)體在應(yīng)激性生活事件后會(huì)表現(xiàn)出更高的抑郁癥狀；男性樣本中,無(wú)顯著交互作用(β=-0.03,p0.05)。 結(jié)論5-HTTLPR對(duì)青少年抑郁癥狀無(wú)預(yù)測(cè)作用；5-HTTLPR與應(yīng)激的交互作用能夠預(yù)測(cè)女性青少年的抑郁癥狀,而對(duì)男性青少年抑郁癥狀沒(méi)有預(yù)測(cè)作用。
[Abstract]:Objective to test the effect of 5-HTTLPRs on depression symptoms in adolescents by using 5-HTTLPR) to test the predictive effect of 5-HTTLPR and stress life events on depression symptoms. Methods A total of 252 freshmen from a high school in Changsha, Hunan Province, were randomly selected and followed up for 2 years and 9 times. Depression symptoms and life events were assessed with the Center for Epidemiological Studies Depression scale (CES-D) and Adolescent Life Events questionnaire (ALEQs), and 5 mL venous blood was extracted to extract DNA and identify 5-HTTLPR genotypes. The depressive symptoms and life events of all subjects were tracked and evaluated every 3 months, and the collected data were statistically analyzed by using the hierarchical Linear Model (HLMModel). Results the multilevel linear model analysis showed that life events had significant predictive effects on both male and female depressive symptoms (male: 尾 = 0.14, p 0.0001; female: 尾 = 0.13, p 0.0001). There was no significant predictive effect of 5-HTTLPR on depressive symptoms in both males and females (male: 尾 0.21, p0.05; female: 尾: 尾 0.21, p0.05; male: 尾 0.21, p0.05; female: 尾: 尾 0.21, p0.0001; male: 尾 0.21, p0.05; male: 尾 0.21, p0.0001; Sex: in female samples, the interaction between 5-HTTLPR and life events was significant (尾 0.08% p0.0001). Individuals with S allele showed higher depressive symptoms after the stress sexual events. There was no significant interaction in male samples (尾 -0.03 P 0.05). Conclusion there is no predictive effect of 5-HTTLPR on depression symptoms in adolescents. The interaction between 5-HTTLPR and stress can predict depression symptoms in female adolescents, but not in male adolescents.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R749.4

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本文編號(hào)：1635778