本文選題：熊果酸　切入點(diǎn)：抗抑郁作用　出處：《現(xiàn)代預(yù)防醫(yī)學(xué)》2017年14期 　論文類型：期刊論文

【摘要】：目的研究熊果酸改善慢性溫和不可預(yù)知應(yīng)激抑郁模型(CUMS)小鼠行為及下丘腦-垂體-腎上腺軸(HPA)軸功能失調(diào)的作用。方法 ICR小鼠接受溫和不可預(yù)知刺激,28 d后經(jīng)糖水偏好實(shí)驗(yàn)評(píng)價(jià)模型,分組:CUMS組、熊果酸干預(yù)組(灌胃,5、10、20 mg/kg)和氟西汀陽性對(duì)照組(灌胃,5 mg/kg),同時(shí)設(shè)置正常組。給藥持續(xù)21 d,最后1周進(jìn)行糖水偏好實(shí)驗(yàn)、礦場(chǎng)試驗(yàn)和強(qiáng)迫游泳實(shí)驗(yàn),評(píng)價(jià)熊果酸對(duì)CUMS小鼠抑郁行為的影響,并檢測(cè)血清促腎上腺皮質(zhì)激素和皮質(zhì)酮及海馬糖皮質(zhì)激素受體蛋白水平的變化,評(píng)價(jià)HPA軸功能。結(jié)果熊果酸增加CUMS小鼠體重(P0.01,P0.001),提高小鼠糖水偏好值(P0.05,P0.01)和自主運(yùn)動(dòng)時(shí)間(水平:P0.01,P0.001;垂直:P0.01,P0.01),并降低強(qiáng)迫游泳不動(dòng)時(shí)間(P0.05,P0.01)。熊果酸還能降低血清促腎上腺皮質(zhì)激素(P0.05)和皮質(zhì)酮水平(P0.05),增加海馬糖皮質(zhì)激素受體蛋白表達(dá)(P0.01)。氟西汀也能抑制CUMS小鼠的抑郁行為和HPA軸的異常變化,其作用效果與高劑量熊果酸的相當(dāng)。結(jié)論熊果酸具有抗抑郁作用,其機(jī)制可能與抑制HPA軸的亢進(jìn)相關(guān)。
[Abstract]:Objective to study the effects of ursolic acid on the behavior and dysfunction of hypothalamus-pituitary-adrenal axis in chronic mild and unpredictable stress depression mice. Methods ICR mice were treated with mild unpredictable stimulation for 28 days. Experimental Evaluation Model of Sugar Water preference, They were divided into two groups: 1 / CUMS group, ursolic acid intervention group (10 ~ 10 mg 路kg ~ (-1) 路kg ~ (-1)) and fluoxetine positive control group (5 mg 路kg ~ (-1) 路kg ~ (-1) 路L ~ (-1) 路L ~ (-1) 路L ~ (-1) 路L ~ (-1) 路L ~ (-1) 路L ~ (-1) 路L ~ (-1) 路L ~ (-1)), respectively. To evaluate the effect of ursolic acid on depressive behavior in CUMS mice and to detect the changes of serum corticotropin and corticosterone and hippocampal glucocorticoid receptor protein. Results ursolic acid increased the body weight of CUMS mice and increased the sugar water preference value (P0.05, P0.01) and autonomous exercise time (horizontal: P0.01P0.01P0.001; Vertical: P0.01P0.01P0.01A, and decreased the immobility time of forced swimming P0.05P0.01. ursolic acid also decreased the serum adrenal cortex stimulating time (P0.05P0.01a). P0.05) and corticosterone increased the expression of glucocorticoid receptor protein in hippocampus. Fluoxetine also inhibited depressive behavior and abnormal changes of HPA axis in CUMS mice. Conclusion ursolic acid has antidepressant effect, and its mechanism may be related to the inhibition of hyperactivity of HPA axis.
【作者單位】： 山東省臨沂市沂水中心醫(yī)院;
【分類號(hào)】：R749.4

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