本文選題：抑郁癥　切入點：溫膽湯　出處：《中國老年學(xué)雜志》2014年13期 　論文類型：期刊論文

【摘要】：目的探討老年抑郁模型大鼠神經(jīng)可塑性變化及溫膽湯的干預(yù)機(jī)制。方法以孤養(yǎng)結(jié)合慢性不可預(yù)見性應(yīng)激老年抑郁模型大鼠為研究對象,在實驗第7、14、21天檢測各組大鼠海馬突觸結(jié)構(gòu)的體視學(xué)變化以及神經(jīng)元再生情況。結(jié)果在抑郁形成過程中,隨著時間的增加,21 d時,與空白組比較,模型組大鼠突觸活性區(qū)長度、突觸后致密物質(zhì)厚度以及NeuN/BrdU、β-tubulinⅢ/BrdU雙標(biāo)陽性細(xì)胞數(shù)均明顯減少,突觸間隙寬度增加明顯(P0.01)。隨著溫膽湯治療時間的增加,上述各指標(biāo)的趨勢均得到抑制(P0.05)。結(jié)論老年抑郁癥患者中存在海馬神經(jīng)突觸結(jié)構(gòu)損傷、神經(jīng)元再生減少等可塑性變化,溫膽湯可通過逆轉(zhuǎn)上述變化而發(fā)揮其抗抑郁的效應(yīng)。
[Abstract]:Objective to explore the changes of neuroplasticity and the intervention mechanism of Wendan decoction in senile depression model rats. The changes of hippocampal synaptic structure and neuronal regeneration in each group were measured on day 7, 14 and 21. Results during the depression formation, the length of synaptic active area in the model group was compared with that in the blank group at 21 days with the increase of time. The thickness of postsynaptic dense substance and the number of Neun / BrdU, 尾 -tubulin 鈪，

本文編號：1590906