本文選題：衰老　切入點：焦慮　出處：《安徽農業(yè)大學學報》2016年06期 　論文類型：期刊論文

【摘要】：探索青年期心理社會環(huán)境改變對中老年CD-1小鼠焦慮和自發(fā)探索活性行為的影響。結果表明,與青年組(3月齡)比較,老年對照組(18月齡)在曠場潛伏期和周邊時間顯著延長,跨格子數顯著減少(Ps0.05);在黑白巷黑端時間和潛伏期顯著延長,黑端到白端次數顯著減少(Ps0.05)。12月齡應激組在曠場周邊時間和在黑白巷黑端時間顯著長于豐富環(huán)境組和對照組,跨越格子數顯著減少(Ps0.05)。18月齡應激組在曠場周邊時間和在黑白巷黑端時間、潛伏期顯著長于豐富環(huán)境組(Ps0.05)。這些提示CD-1小鼠焦慮行為改變具有年齡依賴性,青年期心理社會環(huán)境改變可調節(jié)小鼠年齡相關性焦慮和自發(fā)探索活性行為的改變。
[Abstract]:To explore the effect of psycho-social environment change of youth on anxiety and spontaneous exploring activity in middle-aged and aged CD-1 mice, the results showed that compared with young group (3 months), the aged control group (18 months old) was significantly prolonged in open field latency and peripheral time. In black-and-white lane, the time and latency of black end and white end were significantly prolonged, and the times of black end to white end were significantly decreased in stress group of 12 months old. The time of open field and black end of black and white lane were significantly longer in stress group than those in rich environment group and control group. The lattices crossing significantly decreased the time of open field and black and white lane in stress group of 18 months old, and the latency was significantly longer than that of Ps0.05 in rich environment group, which suggested that anxiety behavior change of CD-1 mice was age-dependent. The change of psycho-social environment in youth can regulate the changes of age-related anxiety and spontaneous exploratory activity in mice.
【作者單位】： 南華大學附屬第一醫(yī)院神經內科;南華大學附屬郴州醫(yī)院神經內科;安徽醫(yī)科大學第一附屬醫(yī)院神經內科;安徽醫(yī)科大學附屬巢湖醫(yī)院神經內科和全科醫(yī)學科;
【基金】：國家自然科學基金(81370444) 國家青年自然科學基金(81301094)共同資助
【分類號】：R749.72
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本文編號：1570652