本文選題：腺苷　切入點(diǎn)：腺苷受體　出處：《藥學(xué)學(xué)報(bào)》2014年06期 　論文類型：期刊論文

【摘要】：腺苷是一種重要的神經(jīng)調(diào)質(zhì),主要通過腺苷受體發(fā)揮各種生理作用。近年研究發(fā)現(xiàn)腺苷受體的分布、類型及表達(dá)變化等與學(xué)習(xí)記憶等認(rèn)知功能關(guān)系密切,在阿爾茨海默病(Alzheimer’s disease,AD)等神經(jīng)退行性疾病發(fā)病中發(fā)揮了重要作用。目前的研究結(jié)果表明,受各種損傷因素的影響,腺苷受體被高水平的腺苷持續(xù)激活而導(dǎo)致腦內(nèi)腺苷受體的失衡,主要表現(xiàn)為A1受體表達(dá)減少和A2a受體表達(dá)升高,以及A1受體介導(dǎo)抑制作用的減弱和A2a受體介導(dǎo)興奮作用的增強(qiáng),進(jìn)而通過各自介導(dǎo)的信號(hào)通路引起一系列神經(jīng)病理變化,最終導(dǎo)致認(rèn)知功能障礙。維持腺苷受體的平衡可能是防治AD的一個(gè)重要途徑,對(duì)其深入研究有助于進(jìn)一步了解AD的發(fā)病機(jī)制,并提供新的治療方向和思路。
[Abstract]:Adenosine is an important neuromodulator that plays a variety of physiological roles mainly through adenosine receptors. In recent years, it has been found that the distribution, type and expression of adenosine receptors are closely related to cognitive functions such as learning and memory. It plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Current studies have shown that adenosine receptors are continuously activated by high levels of adenosine, resulting in the imbalance of adenosine receptors in the brain. The main manifestations were the decrease of A1 receptor expression and the increase of A2a receptor expression, as well as the decrease of A1 receptor mediated inhibition and the enhancement of A2a receptor-mediated excitation, which resulted in a series of neuropathological changes through the respective signaling pathways. Maintaining the balance of adenosine receptor may be an important way to prevent and treat AD. Further study on it will help to further understand the pathogenesis of AD and provide a new treatment direction and ideas.
【作者單位】： 軍事醫(yī)學(xué)科學(xué)院毒物藥物研究所;廣州中醫(yī)藥大學(xué)臨床藥理研究所;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81100239,81302759) 國家重大新藥創(chuàng)制科技重大專項(xiàng)課題資助項(xiàng)目(2012ZX09301003-002)
【分類號(hào)】：R96;R749.16

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