本文選題：輕度認(rèn)知功能障礙　切入點(diǎn)：時(shí)辰　出處：《山東中醫(yī)藥大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：了解不同時(shí)辰輕度認(rèn)知功能障礙患者腦電圖的變化，提煉出客觀可量化的異常指標(biāo)，探索輕度認(rèn)知功能障礙患者腦電圖及MMSE量表的相關(guān)性，為日后早期診斷預(yù)防認(rèn)知功能障礙提供依據(jù)。方法：以我院收治的輕度認(rèn)知功能障礙老年患者30例為研究對(duì)象，并以社會(huì)招募正常健康老年人30例為對(duì)照，，分別進(jìn)行MMSE測(cè)試和24小時(shí)腦電圖監(jiān)測(cè)。選取無(wú)干擾定標(biāo)腦電圖以及子時(shí)、寅時(shí)、辰時(shí)、午時(shí)和申時(shí)、酉時(shí)六個(gè)不同時(shí)辰的腦電圖，比較兩組不同時(shí)辰腦電圖各波功率并對(duì)輕度認(rèn)知功能障礙患者M(jìn)MSE各項(xiàng)評(píng)分與腦電圖相關(guān)性分析。結(jié)果：1.無(wú)干擾定標(biāo)腦電圖病例組和對(duì)照組的雙側(cè)頂枕α功率及大腦各位點(diǎn)的慢波功率差別有統(tǒng)計(jì)學(xué)意義（p㩳0.05）。2.寅時(shí)病例組與對(duì)照組α功率之間的比較有統(tǒng)計(jì)學(xué)意義（p㩳0.05），慢波功率比較無(wú)統(tǒng)計(jì)學(xué)意義（p＞0.05）。3.病例組及對(duì)照組在睡眠2期紡錘波的時(shí)限、頻率及密度差別有統(tǒng)計(jì)學(xué)意義（p㩳0.05）。4.辰時(shí)、午時(shí)、申時(shí)及酉時(shí)病例組和對(duì)照組的雙側(cè)頂枕α功率差別有統(tǒng)計(jì)學(xué)意義（p㩳0.05）；大腦各位點(diǎn)的慢波功率差別有統(tǒng)計(jì)學(xué)意義（p㩳0.05）。5.病例組辰時(shí)、午時(shí)、申時(shí)及酉時(shí)間α功率差別無(wú)統(tǒng)計(jì)學(xué)意義（p＞0.05）。6.病例組的MMSE中時(shí)間定向力、記憶力與腦電圖的慢波或α波存在相關(guān)性（p㩳0.05）。結(jié)論：1.不同時(shí)辰的α波功率、θ和δ波功率及子時(shí)睡眠2期紡錘波的密度、時(shí)限及頻率可以作為診斷輕度認(rèn)知功能障礙的參考指標(biāo)；2.寅時(shí)α波功率下降可以提示早期認(rèn)知功能減退；3.清醒期辰時(shí)、午時(shí)、申時(shí)及酉時(shí)的不同時(shí)辰間輕度認(rèn)知功能障礙的腦電圖差異參考意義不大；4.輕度認(rèn)知功能障礙的MMSE時(shí)間定向力及記憶力與腦電圖α波、θ和δ波的絕對(duì)功率有相關(guān)性。
[Abstract]:Objective: to investigate the changes of electroencephalogram (EEG) in patients with mild cognitive impairment (MCI) at different times, to extract the objective and quantifiable abnormal indexes, and to explore the correlation between EEG and MMSE scale in patients with mild cognitive impairment. Methods: 30 elderly patients with mild cognitive impairment were selected as the study objects, and 30 normal and healthy elderly people were recruited as control. MMSE test and 24 hour EEG monitoring were carried out respectively. The EEG of six different times were selected, including non-interference calibrated EEG and sub-time, Yin, Chen, noon and Shen, and unitary time. The correlation between MMSE scores and EEG in patients with mild cognitive impairment was analyzed. Results: 1. A power of bilateral parietal occipital 偽 and large occipital power in non-interference calibrated EEG group and control group were compared. The difference of slow wave power in each point of the brain is statistically significant. The comparison of 偽 power between the case group and the control group was statistically significant. There was no significant difference in slow wave power between the two groups (P > 0.05). The time limit, frequency and density of spindles in the case group and the control group were significantly different in sleep phase 2. The difference of bilateral parietal occipital 偽 power between the case group and the control group was statistically significant. The difference of slow wave power in each point of the brain is statistically significant. There was no significant difference in 偽 power between the two groups (P > 0.05). Time orientation, memory and slow or 偽 wave of electroencephalogram were correlated with the time orientation in the case group (P > 0.05), and the correlation between the memory and the slow or 偽 wave of EEG was also found in the case group (P > 0.05). Conclusion: 1. 偽 wave power, 胃 and 未 wave power at different times, and density of spindles at sub-sleep stage 2, The time limit and frequency can be used as a reference index for the diagnosis of mild cognitive dysfunction. The decrease of alpha wave power can indicate early cognitive dysfunction. (4) the MMSE time orientation and memory of mild cognitive impairment were correlated with the absolute power of 偽 wave, 胃 wave and 未 wave of EEG.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R749.16

【參考文獻(xiàn)】

相關(guān)期刊論文 前9條

1 李曙光;輕度認(rèn)知障礙和老年性癡呆關(guān)系的研究[J];安徽醫(yī)學(xué);2002年05期

2 楊秀麗;;老年輕度認(rèn)知功能障礙的病因病機(jī)與治療[J];光明中醫(yī);2008年03期

3 馮鋒;尚蘭;曹文勝;蘭志敏;;阿爾茨海默病睡眠腦電圖的研究進(jìn)展[J];國(guó)際精神病學(xué)雜志;2008年01期

4 潘林平;陳國(guó)成;梁慧英;謝西漢;林棣文;;中醫(yī)時(shí)辰觀在缺血性中風(fēng)二級(jí)預(yù)防中的運(yùn)用探析[J];西部中醫(yī)藥;2012年07期

5 田金洲,楊承芝,盛彤,劉桓,JudyHaworth,RomolaBucks,GordonWilcockDM,FRCP;可疑癡呆人群中阿爾茨海默氏病臨床前的認(rèn)識(shí)損害特征及其與中醫(yī)證候的關(guān)系[J];湖北中醫(yī)學(xué)院學(xué)報(bào);1999年04期

6 楊承芝,鐘劍,朱愛(ài)華,田金洲;老年人輕度認(rèn)知損害的中醫(yī)證候研究[J];北京中醫(yī)藥大學(xué)學(xué)報(bào)(中醫(yī)臨床版);2003年02期

7 何迎春;張如富;;輕度認(rèn)知障礙的中醫(yī)辨證分型[J];遼寧中醫(yī)雜志;2006年11期

8 樂(lè)衛(wèi)東;陳晟;;阿爾茨海默病生物學(xué)標(biāo)記和早期診斷研究進(jìn)展[J];老年醫(yī)學(xué)與保健;2005年04期

9 粱紹材，陸泳;52例老年性癡呆的腦電圖[J];臨床腦電學(xué)雜志;1994年02期

本文編號(hào)：1558305