發(fā)布時間：2018-03-01 16:19

  本文關(guān)鍵詞： 香蘭素 抑郁癥 嗅覺通路 單胺類神經(jīng)遞質(zhì)　出處：《中風(fēng)與神經(jīng)疾病雜志》2014年07期 　論文類型：期刊論文

【摘要】：目的研究香蘭素吸嗅對大鼠抑郁樣行為改善及其機制。方法慢性不可預(yù)見性中等強度應(yīng)激(CUMS)+孤養(yǎng)的方法建立大鼠抑郁癥模型。為驗證香蘭素作用途徑,另設(shè)立大鼠嗅球毀損(OBX)模型。于造模前、后及干預(yù)后4 w測試大鼠糖水消耗量和強迫游泳不動時間,干預(yù)結(jié)束后超高壓液相色譜檢測大鼠腦內(nèi)5-HT、DA、NE的量。結(jié)果與造模后相比,CUMS+香蘭素吸嗅組大鼠神經(jīng)行為學(xué)指標(biāo)顯著好轉(zhuǎn)(P0.05);其腦勻漿液5-HT、DA的量顯著高于空白對照組(P0.05)。與造模后相比OBX+香蘭素吸嗅組大鼠神經(jīng)行為學(xué)指標(biāo)未見好轉(zhuǎn)(P0.05);其腦勻漿液5-HT、DA、NE均顯著低于假手術(shù)組(P0.05)。結(jié)論香蘭素可經(jīng)嗅覺通路改善大鼠抑郁樣行為,其機制可能通過提升腦內(nèi)5-HT、DA實現(xiàn)的。
[Abstract]:Objective to study the effect of vanillin sniffing on depressive behavior in rats and its mechanism. Methods the rat model of depression was established by chronic unpredictable medium intensity stress (CUMS) alone. The OBX model of olfactory bulb was established in rats. The consumption of sugar water and the time of forced swimming were measured before, after and 4 weeks after the establishment of the model. Results compared with the model, the neurobehavioral index of rats in CUMS vanillin sniffing group was improved significantly (P 0.05), the brain homogenate of 5-HTDDA was significantly higher than that of the control group (P 0.05), and that of the control group was significantly higher than that of the control group (P < 0.05), and the content of 5-HTTDA in the brain homogenate was significantly higher than that in the control group (P < 0.05). Compared with the OBX vanillin sniffing group, there was no improvement in neurobehavioral indexes, and the brain homogenate 5-HTTD-DAN was significantly lower than that in the sham operation group (P 0.05). Conclusion vanillin can improve the depressive behavior of rats via olfactory pathway. The mechanism may be achieved by enhancing 5-HTDA in the brain.
【作者單位】： 安徽醫(yī)科大學(xué);安徽醫(yī)科大學(xué)人體解剖教研室;安徽醫(yī)科大學(xué)神經(jīng)生物研究所;
【基金】：國家自然科學(xué)基金項目(編號:81000589)
【分類號】：R749.4

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