本文關(guān)鍵詞： 多奈哌齊 尼膜同 腦小血管病 認知功能障礙　出處：《中國老年學(xué)雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的探討多奈哌齊聯(lián)合尼膜同治療腦小血管病致認知功能障礙的臨床療效。方法認知功能障礙腦小血管病患者98例,采用隨機數(shù)字表法分為觀察組(50例)和對照組(48例);對照組給予尼膜同片治療,觀察組給予多奈哌齊聯(lián)合尼膜同治療;采用蒙特利爾(Mo CA)評分評價患者認知功能,對比兩組治療前后血清超敏C反應(yīng)蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平及治療效果。結(jié)果治療前兩組Mo CA評分、血清hsCRP及Hcy水平差異均無統(tǒng)計學(xué)意義(P0.05);治療后兩組Mo CA評分均升高且觀察組高于對照組,血清hs-CRP及Hcy水平均降低,且觀察組均低于對照組,觀察組總有效率高于對照組,差異均有統(tǒng)計學(xué)意義(P0.05);兩組患者治療過程中均未發(fā)生嚴重不良反應(yīng)。結(jié)論尼膜同聯(lián)合多奈哌齊治療腦小血管病認知功能障礙療效更佳,不僅能夠降低患者hs-CRP與Hcy水平,且顯著改善認知功能,具有重要意義。
[Abstract]:Objective to investigate the clinical effect of Donepezil combined with Nimembrane in the treatment of cognitive dysfunction caused by small cerebral vascular disease. The patients were randomly divided into two groups: the observation group (n = 50) and the control group (n = 48). The control group was treated with the same film and the observation group was treated with Donepezil combined with Nim. The cognitive function of the patients was evaluated by the Montreal Mo-CA score. Before and after treatment, the levels of serum hypersensitive C-reactive protein (hs-CRP) and homocysteine cystatin (HCH) were compared between the two groups. Results before and after treatment, there were two groups of Mo CA scores. There was no significant difference in serum hsCRP and Hcy levels between the two groups after treatment, the scores of MoCA in the two groups were increased, the levels of serum hs-CRP and Hcy in the observation group were higher than those in the control group, and the levels of serum hs-CRP and Hcy in the observation group were lower than those in the control group, and the total effective rate in the observation group was higher than that in the control group. There were no serious adverse reactions in both groups. Conclusion Nimembrane combined with Donepezil is more effective in the treatment of cognitive dysfunction in patients with small cerebral vascular disease, and can not only reduce the levels of hs-CRP and Hcy. It is of great significance to improve cognitive function significantly.
【作者單位】： 山東大學(xué)第二醫(yī)院干部保健/老年醫(yī)學(xué)科;山東大學(xué)附屬千佛山醫(yī)院影像科;
【分類號】：R749.13

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本文編號：1541954