本文關(guān)鍵詞： 血管性癡呆 龍生蛭膠囊 氣虛血瘀 血清SB蛋白 人可溶性白細胞分化抗原配體　出處：《中醫(yī)雜志》2014年16期 　論文類型：期刊論文

【摘要】：目的觀察龍生蛭膠囊聯(lián)合西藥治療氣虛血瘀型血管性癡呆(VaD)療效及機制。方法輕度VaD患者80例,按3∶2的比例隨機分為治療組48例與對照組32例。兩組患者除基本治療外,治療組同時給予龍生蛭膠囊每次2.0g口服,每日3次;對照組給予奧拉西坦膠囊每次0.8g口服,每日3次,兩組療程均為6個月。觀察兩組患者治療前后簡易智能狀態(tài)量表(MMSE)、日常生活能力(ADL)、中醫(yī)證候積分和血清S100B蛋白、人可溶性白細胞分化抗原40配體(SCD40L)的變化。結(jié)果患者中醫(yī)證候療效治療組總有效率85.42%,對照組為62.50%,治療組優(yōu)于對照組(P0.05)。治療后治療組除語言積分外,其他各項均較治療前明顯提高(P0.05),對照組定向積分較治療前明顯提高(P0.05),其他各項積分與治療前比較差異無統(tǒng)計學意義(P0.05)。治療后治療組回憶積分及總積分較對照組明顯提高(P0.05);兩組治療后計算、識記、定向與語言積分比較差異均無統(tǒng)計學意義(P0.05)。治療組治療后軀體性日常生活能力積分較治療前和同期對照組降低明顯(P0.05),兩組ADL、工具性日常生活能力積分治療前后以及兩組治療后差異無統(tǒng)計學意義(P0.05)。兩組中醫(yī)證候積分治療后均較治療前降低(P0.05或P0.01),治療組降低更為明顯(P0.05)。兩組患者血清S100B和SCD40L水平治療后均較治療前降低,治療組降低更加明顯(P0.01)。結(jié)論龍生蛭膠囊能聯(lián)合西藥治療氣虛血瘀型血管性癡呆,其作用機制可能與其抗腦組織損傷和炎性反應(yīng)有關(guān)。
[Abstract]:Objective to observe the efficacy and mechanism of Longshengzhi capsule combined with western medicine in treating vascular dementia with Qi deficiency and blood stasis. Methods 80 patients with mild VaD were randomly divided into treatment group (n = 48) and control group (n = 32). The treatment group was given 2.0 g Longshengzhi capsule three times a day, while the control group was given 0.8 g olaxetam capsule three times a day. The two groups were treated for 6 months. MMSE, ADL, TCM syndrome score and serum S100B protein were observed before and after treatment. Results the total effective rate of the treatment group was 85.42, and that of the control group was 62.50. The treatment group was superior to the control group (P 0.05). The other items were significantly higher than those before treatment, the directional integral of the control group was significantly higher than that of the control group, and there was no significant difference between the other scores and that before treatment. After treatment, the recall score and total integral in the treatment group were significantly higher than those in the control group. After treatment, the two groups were calculated, Memorization, The scores of somatic ADL after treatment in the treatment group were significantly lower than those in the control group and before and after treatment. The ADL and instrumental ADL scores in the two groups were significantly decreased before and after treatment. The scores of ADL and ADL before and after treatment in the treatment group were significantly lower than those in the control group before and after treatment. There was no significant difference between the two groups after treatment (P 0.05). After treatment, the scores of TCM syndromes in the two groups were lower than those before treatment (P 0.05 or P 0.01), and the levels of serum S100B and SCD40L in the treatment group were significantly lower than those before treatment, and the levels of serum S100B and SCD40L in the treatment group were lower than those before treatment. Conclusion Longshengzhi capsule can be combined with western medicine to treat vascular dementia with deficiency of qi and blood stasis, and its mechanism may be related to its anti-brain injury and inflammatory reaction.
【作者單位】： 武漢市武昌醫(yī)院;
【分類號】：R749.13
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本文編號：1532609