本文關(guān)鍵詞： CLU 多態(tài)性 阿爾茨海默病　出處：《青島大學(xué)》2011年碩士論文　論文類型：學(xué)位論文

【摘要】：目的探討中國漢族人群CLU基因多態(tài)性與散發(fā)性阿爾茨海默病(sporadic Alzheimer's disease,SAD)的相互關(guān)系。 方法應(yīng)用病例對照的研究方法,我們共入選SAD患者324例,同期年齡和性別完全匹配的對照組388例。多態(tài)性基因分型采用MALDI-TOF質(zhì)譜技術(shù),檢測rs2279590,rs11136000and rs9331888基因型、等位基因多態(tài)性的分布。 結(jié)果CLU基因rs9331888多態(tài)性最小等位基因可顯著增加SAD的發(fā)病風(fēng)險(xiǎn)(OR=1.39,95%CI=1.13-1.72,P=0.002).上述關(guān)聯(lián)性在載脂蛋白E ε4等位基因非攜帶者中,較攜帶者更加明顯。Logistic回歸分析揭示,無論在顯性還是隱性模型中,rs9331888多態(tài)性,與散發(fā)型阿爾茨海默病均有顯著的相關(guān)性。在散發(fā)性阿爾茨海默病患者組和對照組之間,沒有發(fā)現(xiàn)rs2279590和rs11136000基因型和等位基因頻率的顯著差異。單體型分析,確定了風(fēng)險(xiǎn)單倍型(CCG)(OR=1.66,95%CI為1.33-2.07,P0.001)和保護(hù)單體型(CCC)(OR=0.70,95%CI為0.57-0.81,P值0.001)。 結(jié)論CLU基因多態(tài)性與漢族人阿爾茨海默病的易感性相關(guān)聯(lián)。
[Abstract]:Objective to investigate the relationship between CLU gene polymorphism and sporadic Alzheimer's disease of Alzheimer's disease (sad) in Chinese Han population. Methods A case-control study was conducted in 324 SAD patients and 388 age-sex matched controls. The genotypes of Rs2279590 rs11136000 and rs9331888 were detected by MALDI-TOF mass spectrometry. Distribution of allelic polymorphism. Results the minimal allele of rs9331888 polymorphism of CLU gene could significantly increase the risk of SAD. Logistic regression analysis showed that the association was more obvious in apolipoprotein E 蔚 4 alleles than in carriers. Rs9331888 polymorphism was significantly associated with sporadic Alzheimer's disease in both dominant and recessive models. There was no significant difference in genotype and allele frequency between rs2279590 and rs11136000. Haplotype analysis showed that the risk haplotype was 1.33-2.07P0.001 (CI = 1.33-2.07) and the haplotype was 0.700.7095 / CI (P = 0.57-0.81P = 0.001). Conclusion CLU gene polymorphism is associated with susceptibility to Alzheimer's disease in Han Chinese.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R749.16

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 王鈺;張本恕;;炎癥因子基因多態(tài)性及其功能蛋白與阿爾茨海默病的關(guān)系[J];國外醫(yī)學(xué)(老年醫(yī)學(xué)分冊);2008年02期

相關(guān)碩士學(xué)位論文 前1條

1 郁金泰;中國漢族人群ApoE及β2-AR基因多態(tài)性與阿爾茨海默病的關(guān)聯(lián)性研究[D];青島大學(xué);2009年

，

本文編號(hào)：1529354