老年輕度認知功能障礙早期干預的循證與實證研究
發(fā)布時間:2018-02-23 03:22
本文關鍵詞: 輕度認知功能障礙 循證分析 實證研究 干預 出處:《蘇州大學》2013年碩士論文 論文類型:學位論文
【摘要】:目的 1、循證分析各種干預措施對改善老年人輕度認知功能障礙的效果,為實證研究提供一定的參考依據(jù)。 2、實證研究綜合性干預措施對輕度認知功能障礙患者的作用,為改善老年人認知功能、延緩向老年癡呆的轉(zhuǎn)化提供依據(jù)。 方法 1、文獻檢索:通過計算機檢索中國知網(wǎng)全文期刊、重慶維普VIP全文數(shù)據(jù)庫、萬方電子期刊數(shù)據(jù)庫、MEDLINE、SpringerLink電子期刊以及Ovid全文電子數(shù)據(jù)庫,收集國內(nèi)外2000年1月~2012年11月間公開發(fā)表的關于輕度認知功能障礙干預措施的文獻。中文檢索詞為“輕度認知功能損害”、“輕度認知功能障礙”,聯(lián)合關鍵詞為“干預”、“營養(yǎng)干預”、“藥物干預”、“體育鍛煉”、“認知訓練”。檢索外文數(shù)據(jù)庫的主題詞為“Mild Cognitive Impairment”、“Age-Related Cognitive Decline”、“Age-Associated Memory Impairment”、“Intervention”、“Nutrition Intervention”、“MedicineIntervention”、“Physical Activity”、“Cognitive Training”。 2、實證調(diào)查:對社區(qū)老年人進行輕度認知障礙篩查,將篩選出的輕度認知障礙患者隨機分為干預組與對照組,對干預組進行體育鍛煉和認知訓練等方面的干預,對照組仍進行正常的社區(qū)活動。最后采用蒙特利爾量表(MoCA)測量兩組患者在基線、3個月及6個月的認知功能得分情況,評價干預的效果。采用EpiData3.0軟件建立數(shù)據(jù)庫錄入數(shù)據(jù)并校對。采用SPSS17.0對資料進行統(tǒng)計描述。運用獨立樣本的t檢驗比較干預組與對照組的MoCA各項得分情況、用配對的t檢驗分析干預組與對照組的前后得分情況。 結果 1、循證分析:通過對輕度認知障礙的各項干預措施進行meta分析后發(fā)現(xiàn),體育鍛煉和認知訓練以及營養(yǎng)干預里的維生素和地中海飲食的干預結果是有統(tǒng)計學意義的。其合并效應量分別為:體育鍛煉(OR=0.57,95%CI:0.52-0.62)、認知訓練(OR=3.09,95%CI:2.01-4.17)、維生素(OR=0.79,95%CI:0.61-0.98)、地中海飲食(OR=0.61,95%CI:0.49-0.73)。 2、實證研究:對干預組和對照組的基線資料進行比較,結果具有均衡性。干預3個月時,除注意力和總分外,兩組間其他各項MoCA得分的差別都沒有統(tǒng)計學意義(P0.05)。6個月時除視覺網(wǎng)與執(zhí)行功能和抽象記憶外,,其他各項得分及總分的差別都具有統(tǒng)計學意義(P0.05)。 結論 1、循證研究發(fā)現(xiàn)體育鍛煉和認知訓練以及營養(yǎng)干預里的維生素和地中海飲食能夠在一定程度上改善老年人的認知功能,這為實證研究提供了一定依據(jù)。 2、實證研究發(fā)現(xiàn),經(jīng)過3-6個月體育鍛煉和認知訓練相結合的綜合性干預,對輕度認知障礙患者的認知功能改善是有效果的。
[Abstract]:Purpose 1 . Evidence - based analysis of the effects of various intervention measures on the improvement of mild cognitive impairment in the elderly provides some reference for the empirical research . 2 . The effect of comprehensive intervention measures on patients with mild cognitive impairment was studied in order to improve the cognitive function of the elderly and delay the transformation of senile dementia . method 1 . Literature search : A literature search of mild cognitive impairment interventions published between January 2000 and November 2012 was collected from January 2000 to November 2012 . The Chinese search term was " Mild Cognitive Impairment " , " Mild Cognitive Impairment " , " Intervention " , " Nutrition Intervention " , " Drug Intervention " , " Physical Exercise " , " Cognitive Training " . The subject words " Age - Related Cognitive Impairment " , " Age - Associated Memory " , " Physical Activity " , " Nutrition Training " were retrieved . 2 . Positive investigation : The patients with mild cognitive impairment were randomly divided into the intervention group and the control group , and the intervention group was divided into the intervention group and the control group , and the control group still carries out normal community activities . Results 1 . Evidence - based analysis : After meta - analysis of the intervention measures of mild cognitive impairment , it was found that physical exercise and cognitive training and the intervention of vitamin and Mediterranean diet were statistically significant in physical exercise ( OR = 0.57 , 95 % CI : 0.52 - 0.62 ) , cognitive training ( OR = 3.09 , 95 % CI : 2.01 - 4.17 ) , vitamin ( OR = 0.79 , 95 % CI : 0.61 - 0.98 ) , Mediterranean diet ( OR = 0.61 , 95 % CI : 0.49 - 0.73 ) . 2 . Positive research : Compared with the baseline data from the intervention group and the control group , the results showed that there was no significant difference between the two groups except attention and total score ( P0.05 ) . Conclusion 1 . Evidence - based research has found that physical exercise and cognitive training and vitamin and Mediterranean diet in nutrition intervention can improve the cognitive function of the elderly to a certain extent , which provides a basis for the empirical research . 2 . The empirical study found that the comprehensive intervention combined with 3 - 6 months of physical exercise and cognitive training was effective in improving cognitive function in patients with mild cognitive impairment .
【學位授予單位】:蘇州大學
【學位級別】:碩士
【學位授予年份】:2013
【分類號】:R749.16
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