本文關(guān)鍵詞： 阿戈美拉汀 抑郁癥 Meta分析 隨機(jī)對(duì)照試驗(yàn)　出處：《重慶醫(yī)科大學(xué)學(xué)報(bào)》2017年10期 　論文類型：期刊論文

【摘要】：目的:利用Meta分析的方法分別評(píng)估阿戈美拉汀與選擇性5-羥色胺再攝取抑制劑(selective serotonin reuptake inhibitor,SSRI)、選擇性5-羥色胺和去甲腎上腺素再攝取抑制劑(serotonin noradrenaline reuptake inhibitor,SNRI)類藥物治療抑郁癥的療效,為臨床治療提供參考。方法:計(jì)算機(jī)檢索Cochrane library、Pubmed、Elsevier、中國(guó)知網(wǎng)、維普數(shù)據(jù)庫(kù)、中國(guó)生物醫(yī)學(xué)數(shù)據(jù)庫(kù)、萬(wàn)方數(shù)據(jù)庫(kù),收集阿戈美拉汀與SSRI、SNRI類藥物治療抑郁癥的隨機(jī)對(duì)照試驗(yàn)(randomized controlled trial,RCT),對(duì)符合納入標(biāo)準(zhǔn)的臨床研究進(jìn)行質(zhì)量評(píng)價(jià)和資料提取后,采用Rev Man5.2統(tǒng)計(jì)軟件進(jìn)行Meta分析。結(jié)果:研究共納入8項(xiàng)RCTs,總計(jì)2 632例患者;Meta分析結(jié)果顯示,阿戈美拉汀組患者有效率(RR=1.07,95%CI=1.01~1.12,P=0.010)、治愈率(RR=1.10,95%CI=1.01~1.20,P=0.030)均明顯高于SSRI、SNRI類藥物組,抑郁量表終點(diǎn)評(píng)分與基線的差值值高于SSRI、SNRI類藥物組(MD=0.46,95%CI=-0.13,1.05,P=0.130),2組差異無(wú)統(tǒng)計(jì)學(xué)意義。阿戈美拉汀在不良反應(yīng)反應(yīng)方面優(yōu)于SSRI、SNRI類藥物組(RR=0.50,95%CI=0.37~0.68,P=0.000),差異存在統(tǒng)計(jì)學(xué)意義。結(jié)論:阿戈美拉汀較其他SSRI、SNRI類藥物治療抑郁癥的療效更好、更安全。尚需高質(zhì)量、大樣本RCT研究進(jìn)一步驗(yàn)證。
[Abstract]:Objective: to evaluate the efficacy of agomelatin, selective serotonin reuptake inhibitor, selective serotonin and norepinephrine reuptake inhibitor, serotonin noradrenaline reuptake inhibitor SNRI, in the treatment of depression. Methods: to search Cochrane librarylary pubmedmedus Elsevier, China knowledge Network, Weip Database, Chinese Biomedical Database, Wanfang Database, and to provide reference for clinical treatment. A randomized controlled trial of Agonelatin and SSRI SNRI in the treatment of depression was conducted, and the quality evaluation and data extraction of the clinical studies that met the inclusion criteria were carried out. Results: a total of 2 632 patients were included in the study. The results of meta-analysis showed that the effective rate of patients in the Agonolatine group was 1.01 ~ 1.12 ~ 1. 12% P0. 010 ~ 0, and the cure rate was significantly higher than that in the SSRI SNRI group, and the cure rate was significantly higher than that in the SSRI SNRI group, and the cure rate was higher than that in the SSRI SNRI group, and the cure rate was significantly higher than that in the SSRI SNRI group, and the cure rate was significantly higher than that in the SSRI SNRI group, and the cure rate was significantly higher than that in the SSRI SNRI group. The difference between the end point score and baseline score of depression scale was higher than that in SSRI SSRI SNRI group. There was no significant difference between the two groups. Agomelatin was better than SSRI SNRI group in adverse reactions, RR0.5095CI0.370.68P0.0000.Conclusion: there is a significant difference between two groups. Melatine is more effective in the treatment of depression than other SSRI- SNRI drugs. Safer. High quality, large sample RCT research is needed for further validation.
【作者單位】： 南昌大學(xué)第一附屬醫(yī)院心身醫(yī)學(xué)科;南昌大學(xué)第一附屬醫(yī)院康復(fù)醫(yī)學(xué)科;
【分類號(hào)】：R749.4

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