發(fā)布時(shí)間：2018-01-17 14:42

  本文關(guān)鍵詞：慢性萎縮性胃炎伴焦慮抑郁中醫(yī)證型的分布特點(diǎn)及胃腸激素的相關(guān)性研究　出處：《福建中醫(yī)藥大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 慢性萎縮性胃炎 焦慮抑郁 中醫(yī)證型 胃泌素 胃動(dòng)素

【摘要】：目的：通過調(diào)查慢性萎縮性胃炎(Chronic Atrophic Gastritis, CAG)伴焦慮抑郁人群的中醫(yī)證型及檢測(cè)胃泌素(Gastrin, GAS)、胃動(dòng)素(Motilin,MTL),得出CAG伴焦慮抑郁人群的中醫(yī)證型分布特點(diǎn),及與GAS、MTL的相關(guān)性,進(jìn)一步探討情志因素在CAG發(fā)病中對(duì)中醫(yī)證型及GAS、MTL的影響,為CAG伴焦慮抑郁人群進(jìn)行中西醫(yī)結(jié)合防治的研究提供參考依據(jù)。 方法：收集符合條件并經(jīng)綜合醫(yī)院焦慮抑郁量表(Hospital anxiety and depression scale, HAD)評(píng)估的89例CAG患者,HAD量表得分≥8分60例,HAD量表得分8分29例。受試者根據(jù)中醫(yī)證型標(biāo)準(zhǔn)進(jìn)行辨證,空腹行胃鏡檢查時(shí)取胃黏膜組織,標(biāo)本采集后進(jìn)行RNA提取、反轉(zhuǎn)錄反應(yīng)、PCR反應(yīng)后得出mRNA的表達(dá)量。用統(tǒng)計(jì)學(xué)方法,對(duì)焦慮抑郁及非焦慮抑郁人群中醫(yī)證型進(jìn)行比較,焦慮抑郁及非焦慮抑郁人群GAS、 MTL進(jìn)行比較,及各中醫(yī)證型與GAS、MTL進(jìn)行比較。 結(jié)果：焦慮抑郁組與非焦慮抑郁組中醫(yī)證型比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05)焦慮抑郁組以肝胃不和證為主證多見,或兼以脾胃濕熱、脾胃虛弱,非焦慮抑郁組以脾胃濕熱證、脾胃虛弱證多見。焦慮抑郁組與非焦慮抑郁組Hp感染率、萎縮程度、腸化程度比較差異無統(tǒng)計(jì)學(xué)意義(P0.05)。焦慮抑郁組GAS、MTL的mRNA表達(dá)量低于非焦慮抑郁組(P0.05)。焦慮抑郁組與非焦慮抑郁組主要中醫(yī)證型與GAS、MTL的mRNA表達(dá)量比較：焦慮抑郁組肝胃不和+脾胃濕熱證、肝胃不和+脾胃虛弱證GAS的mRNA表達(dá)量低于肝胃不和證(P0.05),三個(gè)主要證型MTL比較差異無統(tǒng)計(jì)學(xué)意義(P0.05)；非焦慮抑郁組脾胃濕熱證GAS、MTL的mRNA表達(dá)量均高于脾胃虛弱證(P0.05)。 結(jié)論：焦慮抑郁因素對(duì)CAG的中醫(yī)證型有一定影響,焦慮抑郁人群相比非焦慮抑郁人群胃腸激素(GAS、MTL)變化更為顯著。焦慮抑郁與非焦慮抑郁各組中醫(yī)證型與胃腸激素比較部分存在聯(lián)系,GAS、MTL水平變化部分反映了CAG中醫(yī)證型間的差異,在診治CAG時(shí),除需考慮病因病癥相結(jié)合外,仍需考慮情志因素對(duì)疾病證型及發(fā)展的影響,重視疾病的社會(huì)心理因素,各種心理干預(yù)對(duì)防治脾胃病有其有效性和必要性。
[Abstract]:Objective: to investigate chronic Atrophic Gastritis in chronic atrophic gastritis. The TCM syndromes of patients with anxiety and depression and the detection of gastrin, gastrin, motilinia motilinus MTL. The distribution characteristics of TCM syndromes of CAG with anxiety and depression and the correlation with GAS-MTL were obtained, and the influence of emotional factors on TCM syndromes and GAS-MTL in the pathogenesis of CAG was further discussed. To provide a reference for the study of the prevention and treatment of CAG with anxiety and depression. Methods: hospital anxiety and depression scale was collected according to the criteria and tested by the General Hospital anxiety and Depression scale. Among 89 patients with CAG, the score of had scale was 鈮，

本文編號(hào)：1436704