發(fā)布時(shí)間：2019-07-21 20:30

【摘要】：目的觀察血栓通對(duì)顱外傷合并多發(fā)性肋骨骨折患者的臨床療效。方法 66例顱外傷合并多發(fā)性肋骨骨折患者隨機(jī)分為對(duì)照組33例和試驗(yàn)組33例。2組均實(shí)施手術(shù)糾正及持續(xù)吸氧、降顱壓、神經(jīng)營(yíng)養(yǎng)支持、糾正水電解質(zhì)紊亂、對(duì)癥治療等治療。試驗(yàn)組在此基礎(chǔ)上,靜脈滴注血栓通注射液5 m L,溶于5%葡萄糖溶液250 m L,每日1次,持續(xù)14 d。比較2組患者治療前、治療7,14 d后疼痛評(píng)分、血氧飽和度變化和神經(jīng)功能缺損程度評(píng)分;根據(jù)患者病情分為Ⅰ、Ⅱ、Ⅲ級(jí),比較各級(jí)患者呼吸機(jī)使用時(shí)間、止痛藥使用時(shí)間及住院時(shí)間。結(jié)果治療7,14 d后,試驗(yàn)組的疼痛視覺模擬評(píng)分(VAS)分別為(2.33±0.51),(1.20±0.38)分,對(duì)照組的VAS分別為(7.05±1.39),(2.81±0.40)分;試驗(yàn)組神經(jīng)功能缺損程度評(píng)分量表(NDS)評(píng)分分別為(10.70±2.99),(8.06±3.38)分,對(duì)照組的NDS評(píng)分分別為(15.84±4.62),(11.29±2.58)分,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療7,14 d后,試驗(yàn)組的動(dòng)脈血氧飽和度(SpO_2)分別為(90.36±3.55)%,(95.52±4.07)%;對(duì)照組的Sp O2分別為(89.81±3.42)%,(94.71±3.96)%,2組與治療前相比,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。試驗(yàn)組Ⅰ、Ⅱ、Ⅲ級(jí)患者呼吸機(jī)使用時(shí)間分別為0,(1.13±0.96),(4.02±3.70)d;對(duì)照組Ⅰ、Ⅱ、Ⅲ級(jí)患者呼吸機(jī)使用時(shí)間分別為0,(4.59±3.05),(7.96±6.13)d;試驗(yàn)組Ⅰ、Ⅱ、Ⅲ級(jí)患者止痛藥使用時(shí)間分別為(2.09±0.58),(4.71±0.83),(7.09±1.25)d,對(duì)照組Ⅰ、Ⅱ、Ⅲ級(jí)患者止痛藥使用時(shí)間分別為(4.31±1.07),(8.20±3.55),(13.26±5.81)d;試驗(yàn)組Ⅰ、Ⅱ、Ⅲ級(jí)患者住院時(shí)間分別為(10.69±3.75),(15.36±8.22),(18.31±5.07)d,對(duì)照組Ⅰ、Ⅱ、Ⅲ級(jí)患者住院時(shí)間分別為(17.26±3.58),(19.39±5.42),(30.05±2.44)d,2組差異有統(tǒng)計(jì)學(xué)意義(P0.05)。2組均未發(fā)生藥物不良反應(yīng)。結(jié)論血栓通能夠有效改善顱外傷合并多發(fā)性肋骨骨折患者臨床癥狀,促進(jìn)其神經(jīng)功能及機(jī)體狀態(tài)的恢復(fù),有助于縮短住院時(shí)間和止痛藥物用量,對(duì)患者預(yù)后質(zhì)量的改善具有積極作用。
[Abstract]:Objective To observe the clinical effect of thrombi on the patients with multiple rib fractures. Methods Sixty-six patients with multiple rib fractures were randomly divided into the control group (33 cases) and the test group (33 cases). On the basis of this, the group of 5% glucose solution was dissolved in 5% glucose solution for 14 days, and the scores of pain, blood oxygen saturation and the degree of neurological deficit were assessed before and after treatment for 7 and 14 days. According to the condition of the patient, the use time of the ventilator, the use time of the analgesic and the hospital stay time are compared. Results After 7 and 14 days of treatment, the visual analogue scores (VAS) of the test group were (2.33-0.51), (1.20-0.38), and the VAS of the control group was (7.05-1.39), (2.81-0.40), and the scores of the neurological deficit scores (NDS) in the test group were (10.70-2.99), respectively. (8.06-3.38), the NDS scores of the control group were (15.84-4.62), (11.29-2.58), and the difference was significant (P0.05). After 7 and 14 days, the arterial oxygen saturation (SpO _ 2) in the test group was (90.36-3.55)%, (95.52-4.07)%, respectively (89.81-3.42)%, (94.71-3.96)% in the control group, and the difference was statistically significant (P0.05). The use time of the ventilator was 0, (1.13, 0.96), (4.02, 3.70) d in the test group,0, (4.59, 3.05), (7.96 to 6.13) d in the control group, (7.96, 6.13) d, and the test groups I and II, respectively. The use time of the pain-relievers in stage 鈪，

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