發(fā)布時(shí)間：2019-07-09 13:10

【摘要】：目的:探討葉酸和維生素B12對急性缺血性腦卒中預(yù)后的影響。方法:選取急性缺血性腦卒中患者132例為觀察組,健康體檢者100例為對照組。采用改良Rankin量表評估,分為預(yù)后良好組(m RS0~2分)和預(yù)后不良好組(m RS 3~6分,其中6分代表死亡),分析入院時(shí)葉酸和維生素B12的水平及預(yù)后相關(guān)性。結(jié)果:急性缺血性腦卒中患者葉酸含量明顯低于對照組[(5.84±2.83)ng/m L vs.(8.83±3.4)ng/m L,P0.001],維生素B12含量明顯低于對照組[(444.61±254.08)pg/m L vs.(566.55±116.61)ng/m L,P0.001]。急性缺血性腦卒中患者預(yù)后不良組的葉酸含量低于預(yù)后良好組[(3.90±1.39)ng/m L vs.(6.42±2.89)ng/m L,P0.001],預(yù)后不良組的維生素B12含量明顯低于預(yù)后良好組[(322.36±154.98)pg/m L vs.(480.56±266.62)pg/m L,P=0.002]。相關(guān)性分析顯示葉酸及維生素B12與m RS均呈負(fù)相關(guān)(r=-0.447,P0.001;r=-0.231,P=0.008)。結(jié)論:葉酸和維生素B12是急性缺血性腦卒中潛在的預(yù)后評估標(biāo)志物。
[Abstract]:Objective: to investigate the effect of folic acid and vitamin B 12 on the prognosis of acute ischemic stroke. Methods: 132 patients with acute ischemic stroke were selected as observation group and 100 healthy subjects as control group. The modified Rankin scale was used to evaluate the patients with good prognosis (m RS0~2 score) and poor prognosis group (m RS 3 ~ 6 points, in which 6 points represented death). The levels of folic acid and vitamin B12 at admission and the correlation between prognosis were analyzed. Results: the folic acid content in patients with acute ischemic stroke was significantly lower than that in the control group [(5.84 鹵2.83) ng/m L vs. (8.83 鹵3.4) ng/m / L, P0.001], and the vitamin B12 content in the control group was significantly lower than that in the control group [(444.61 鹵254.08) pg/m L vs. (566.55 鹵116.61 ng/m / L, P0.001]. The folic acid content in the poor prognosis group was lower than that in the good prognosis group [(3.90 鹵1.39) ng/m L vs. (6.42 鹵2.89) ng/m / L, P0.001]. The vitamin B12 content in the poor prognosis group was significantly lower than that in the good prognosis group [(322.36 鹵154.98) pg/m L vs. (480.56 鹵266.62 pg/m / L, P 鈮，

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