【摘要】：目的觀察腹腔鏡術后腹腔灌洗、持續(xù)循環(huán)式腹膜透析(CCPD)治療重癥急性胰腺炎(SAP)的臨床效果及安全性。方法將68例SAP患者隨機分為治療組32例與對照組36例,治療組于腹腔鏡下手術,術后灌洗引流與CCPD交替進行,病情穩(wěn)定后(約需3 d)單一行腹腔灌洗;對照組給予常規(guī)治療。結果治療組急性生理與慢性健康評分(APACHEⅡ)及Balthazar CT積分從第1天即下降明顯(P0.05),而對照組在第3天才顯著下降,且治療組各時點積分均較對照組明顯降低(P0.05)。治療組各時相點血漿中促炎細胞因子腫瘤壞死因子-α(TNF-α)、白細胞介素-6(IL-6)、白細胞介素-8(IL-8)及C反應蛋白(CRP)含量與治療前比較呈明顯降低趨勢(P0.01),白細胞介素-10(IL-10)含量呈明顯升高趨勢(P0.01),與對照組比較各時點各細胞因子含量差異有統(tǒng)計學意義意義(P0.05)。結論腹腔鏡術后灌洗引流與CCPD治療SAP具有方法簡單、安全、快捷、創(chuàng)傷小、并發(fā)癥少及無需抗凝等優(yōu)點,無血液動力學影響,患者有較好的耐受性等特點,是一種治療SAP的有效方法。
[Abstract]:Objective to observe the efficacy and safety of peritoneal lavage and continuous circulation peritoneal dialysis (CCPD) in the treatment of severe acute pancreatitis (SAP) after laparoscopic surgery. Methods 68 patients with SAP were randomly divided into treatment group (n = 32) and control group (n = 36). The patients in the treatment group were operated under laparoscopy, the drainage was alternately performed with CCPD after operation, and the patients in the control group were given routine treatment after stable condition (about 3 days). Results the acute physiological and chronic health scores (APACHE 鈪，

本文編號：2432611