發(fā)布時(shí)間：2018-12-05 21:21

【摘要】：目的觀察參附注射液(去甲烏頭堿和人參皂苷)聯(lián)合重組人腦利鈉肽(rh BNP)治療急性左心衰竭(ALHF)療效。方法將203例ALHF患者隨機(jī)分為兩組,對(duì)照組101例在常規(guī)治療基礎(chǔ)上靜脈輸注凍干rh BNP注射液,治療組102例在對(duì)照組基礎(chǔ)上加用參附注射液,觀察兩組療效和藥物副作用。結(jié)果治療組總有效率顯著高于對(duì)照組;治療后兩組血漿人腦利鈉肽(BNP)水平顯著降低,治療組治療后血漿BNP水平較對(duì)照組顯著降低;兩組左室射血分?jǐn)?shù)(LVEF)和左室短軸縮短率(LVFS)較治療前顯著升高,左室舒張末內(nèi)徑(LVEDD)顯著降低,治療組治療后LVEF和LVFS較對(duì)照組顯著升高,LVEDD顯著降低;治療組治療后血肌酐(SCr)和尿素氮(BUN)水平較治療前顯著降低,與對(duì)照組比較顯著降低。治療組低血壓反應(yīng)發(fā)生率低于對(duì)照組。結(jié)論參附注射液聯(lián)合rh BNP治療ALHF療效較好,值得臨床應(yīng)用。
[Abstract]:Objective to observe the therapeutic effect of Shenfu injection (noraconitine and ginsenoside) combined with recombinant human brain natriuretic peptide (rh BNP) on acute left heart failure (ALHF). Methods 203 patients with ALHF were randomly divided into two groups: the control group (101 cases) received freeze-dried rh BNP injection on the basis of routine treatment, and the treatment group (102 cases) received Shenfu injection on the basis of the control group. The curative effect and side effects of the two groups were observed. Results the total effective rate in the treatment group was significantly higher than that in the control group, the plasma levels of human brain natriuretic peptide (BNP) in the two groups were significantly decreased after treatment, and the plasma BNP level in the treatment group was significantly lower than that in the control group. Left ventricular ejection fraction (LVEF), left ventricular shortening rate (LVFS) and left ventricular end-diastolic diameter (LVEDD) were significantly increased and left ventricular end-diastolic diameter (LVEDD) decreased in both groups. After treatment, LVEF and LVFS in the treatment group were significantly higher than those in the control group, and LVEDD was significantly decreased. The levels of serum creatinine (SCr) and urea nitrogen (BUN) in the treatment group were significantly lower than those before treatment and significantly lower than those in the control group. The incidence of hypotension in the treatment group was lower than that in the control group. Conclusion Shenfu injection combined with rh BNP is effective in the treatment of ALHF and is worthy of clinical application.
【作者單位】： 黃淮學(xué)院附屬醫(yī)院;
【分類號(hào)】：R541.6
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本文編號(hào)：2365486