【摘要】：目的研究早期持續(xù)性血液濾過聯(lián)合宣白承氣湯對膿毒癥肺損傷的治療效果。方法選取48例ICU初診為膿毒癥肺損傷患者,隨機分為對照組和觀察組,每組24例。對照組給予連續(xù)性靜脈-靜脈血液濾過(CVVH)治療,觀察組在對照組治療基礎(chǔ)上加用宣白承氣湯治療。比較兩組患者的住院時間、機械通氣時間、ICU滯留時間,比較兩組患者治療前后氧合指數(shù)(PaO_2/FiO_2)、平均動脈壓(MAP)、血乳酸(LAC)、血肌酐(SCr)、超敏C反應(yīng)蛋白(hs-CRP)、急性生理與慢性健康(APACHEⅡ)評分。結(jié)果觀察組的住院時間、機械通氣時間、ICU滯留時間顯著短于對照組,差異有統(tǒng)計學(xué)意義(P0.01)。兩組治療后的PaO_2/FiO_2、MAP、LAC、SCr、hs-CRP水平及APACHEⅡ評分等指標(biāo)均顯著低于治療前,差異有統(tǒng)計學(xué)意義(P0.05)。治療后,觀察組的PaO_2/FiO_2、MAP、LAC、SCr、hs-CRP水平及APACHEⅡ評分顯著低于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論在CVVH治療的基礎(chǔ)上加用宣白承氣湯治療膿毒癥肺損傷患者,可進(jìn)一步縮短患者的治療時間,進(jìn)一步改善患者的急性生理功能和慢性健康狀態(tài),有著更為顯著的臨床效果。
[Abstract]:Objective to study the therapeutic effect of early continuous hemofiltration combined with Xuanbai Chengqi decoction on septic lung injury. Methods 48 ICU patients with septic lung injury were randomly divided into control group (n = 24) and observation group (n = 24). The control group was treated with continuous veno-venous hemofiltration (CVVH), the observation group was treated with Xuanbai Chengqi decoction on the basis of the control group. The hospitalization time, mechanical ventilation time and ICU retention time were compared between the two groups. The oxygenation index (PaO_2/FiO_2), mean arterial pressure (MAP), lactate (LAC), serum creatinine (SCr), were compared before and after treatment. Hypersensitive C-reactive protein (hs-CRP), acute physiological and chronic health (APACHE 鈪，

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