【摘要】：目的： 動(dòng)態(tài)觀察氧化低密度脂蛋白(Ox-LDL)、血栓前體蛋白(TpP)在急性腦梗死中的表達(dá),并探討其臨床意義。 方法： 采用酶聯(lián)免疫吸附測(cè)定(ELISA)法測(cè)定44例腦梗死患者急性期、恢復(fù)期組及30例健康對(duì)照者血清Ox-LDL和血漿TpP水平,并對(duì)腦梗死患者行美國(guó)國(guó)立衛(wèi)生研究院卒中量表(NIHSS)評(píng)分,分析Ox-LDL、TpP在急性腦梗死中的表達(dá)及與NIHSS評(píng)分的關(guān)系。 結(jié)果： 腦梗死患者血清Ox-LDL和血漿TpP均較對(duì)照組升高,急性期組Ox-LDL及TpP顯著高于恢復(fù)期組及對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.01)；腦梗死組血漿TpP濃度與NIHSS評(píng)分呈正相關(guān)(P0.01),Ox-LDL濃度高低與NIHSS評(píng)分無(wú)關(guān)(P0.05)；腦梗死組Ox-LDL與TpP水平呈正相關(guān)(r=0.521,P0.05)。 結(jié)論： 急性腦梗死患者血清Ox-LDL、血漿TpP表達(dá)上調(diào),且其水平隨臨床病程不同而發(fā)生變化,它們可能共同參與了急性腦梗死的發(fā)生、發(fā)展過(guò)程；血漿TpP可能與腦梗死嚴(yán)重程度相關(guān),或可作為急性腦梗死病情及預(yù)后判斷的指標(biāo)。
[Abstract]:Aim: to investigate the expression of oxidized low density lipoprotein (Ox-LDL) and thromboprecursor protein (TpP) in acute cerebral infarction and its clinical significance. Methods: the levels of serum Ox-LDL and plasma TpP in 44 patients with acute cerebral infarction, in convalescent group and 30 healthy controls were measured by (ELISA) assay. The (NIHSS) score of stroke scale of the National Institutes of Health (NIH) was used to analyze the expression of Ox-LDL,TpP in acute cerebral infarction and the relationship between Ox-LDL,TpP and NIHSS score. Results: the serum Ox-LDL and plasma TpP in patients with cerebral infarction were higher than those in the control group. The Ox-LDL and TpP in the acute phase group were significantly higher than those in the convalescent group and the control group (P0.01). There was a positive correlation between plasma TpP concentration and NIHSS score in cerebral infarction group (P0.01), but no correlation between Ox-LDL concentration and NIHSS score (P0.05), and there was a positive correlation between Ox-LDL and TpP level in cerebral infarction group (r = 0.521 P 0.05). Conclusion: the expression of serum Ox-LDL, TpP is up-regulated in patients with acute cerebral infarction, and its level changes with the clinical course. They may be involved in the occurrence and development of acute cerebral infarction. Plasma TpP may be related to the severity of cerebral infarction, or may be used as an indicator of the severity and prognosis of acute cerebral infarction.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類(lèi)號(hào)】：R743.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前7條

1 趙銳,范純武,張穎;血栓前體蛋白含量變化與年齡的關(guān)系[J];微循環(huán)學(xué)雜志;2005年01期

2 俞龍;楊德剛;王曉鈴;袁成林;吳健;劉筱潔;;血栓前體蛋白與缺血性腦血管疾病關(guān)系的研究[J];實(shí)用臨床醫(yī)藥雜志;2005年11期

3 張惠敏,馮景昌,李庭富,陳諒;缺血性腦血管病患者血清高密度脂蛋白含量的測(cè)定[J];中風(fēng)與神經(jīng)疾病雜志;2000年03期

4 魏崗之;應(yīng)重視腦卒中的綜合預(yù)防[J];中華神經(jīng)科雜志;2002年05期

5 易興陽(yáng);陳存木;池麗芬;黃毅;張順開(kāi);;頸動(dòng)脈粥樣硬化與進(jìn)展性缺血性腦卒中的關(guān)系[J];中華神經(jīng)科雜志;2006年06期

6 梁國(guó)威;趙媛;單華;徐旭;王樹(shù)琴;;腦血管病患者總同型半胱氨酸水平與血肌酐相關(guān)性及腎臟代償調(diào)節(jié)的性別差異分析[J];中華檢驗(yàn)醫(yī)學(xué)雜志;2006年03期

7 王春燕;張愛(ài)民;賈玫;;超敏C反應(yīng)蛋白和血管性假性血友病因子對(duì)高血壓合并頸動(dòng)脈粥樣硬化的診斷價(jià)值[J];中國(guó)實(shí)驗(yàn)診斷學(xué);2010年07期

，

本文編號(hào)：2338774