【摘要】：目的觀察單唾液酸四己糖神經(jīng)節(jié)苷脂(GM1)聯(lián)合高壓氧治療急性腦梗死的臨床療效。方法將80例急性腦梗死患者隨機(jī)分為常規(guī)治療組(40例)和聯(lián)合治療組(40例)。兩組均常規(guī)予以阿托伐他汀分散片、拜阿司匹林腸溶片、血栓通、巴曲酶治療,并輔以控制血壓、血糖等治療。聯(lián)合治療組在常規(guī)治療基礎(chǔ)上予以GM1(生理鹽水+GM1 40 mg/d)聯(lián)合高壓氧治療,療程10 d。治療前后分別采用NIHSS、日常生活活動(dòng)量表(ADL)的Barthel指數(shù)評(píng)價(jià)患者的神經(jīng)功能;治療3個(gè)月后對患者進(jìn)行mRS評(píng)分。結(jié)果治療前常規(guī)治療組及聯(lián)合治療組患者NIHSS評(píng)分及Barthel指數(shù)差異無統(tǒng)計(jì)學(xué)意義(均P0.05)。與治療前比較,常規(guī)治療組及聯(lián)合治療組治療后Barthel指數(shù)顯著升高,NIHSS評(píng)分顯著降低(均P0.01)。與常規(guī)治療組比較,聯(lián)合治療組治療后NIHSS評(píng)分及mRS評(píng)分顯著降低,Barthel指數(shù)評(píng)分顯著升高(均P0.05)。聯(lián)合治療組總有效率顯著高于常規(guī)治療組(χ~2=5.00,P=0.025)。兩組患者均未發(fā)生明顯的不良反應(yīng)。結(jié)論對于未能進(jìn)行溶栓治療的急性腦梗死患者,積極予以常規(guī)治療可改善患者預(yù)后;在此基礎(chǔ)上的進(jìn)行GM1聯(lián)合高壓氧治療更能有效促進(jìn)急性腦梗死患者神經(jīng)功能狀態(tài)的康復(fù)和遠(yuǎn)期療效,且安全有效,值得臨床推廣。
[Abstract]:Objective to observe the clinical effect of monosialic tetrahexose ganglioside (GM1) combined with hyperbaric oxygen in the treatment of acute cerebral infarction. Methods 80 patients with acute cerebral infarction were randomly divided into routine treatment group (40 cases) and combined treatment group (40 cases). Both groups were treated with Atto vastatin dispersible tablets, aspirin enteric-coated tablets, Xueshuantong, batroxobin, and blood pressure control, blood sugar treatment. The combined treatment group was treated with GM1 (normal saline GM1 40 mg/d) and hyperbaric oxygen on the basis of routine treatment for 10 days. Before and after treatment, the Barthel index of NIHSS, ADL scale (ADL) was used to evaluate the neurological function of the patients, and the mRS score was evaluated after 3 months of treatment. Results there was no significant difference in NIHSS score and Barthel index between routine treatment group and combined treatment group before treatment (P0.05). Compared with before treatment, Barthel index and NIHSS score in routine treatment group and combined treatment group were significantly increased (P0.01). Compared with the conventional treatment group, the combined treatment group after treatment significantly decreased the NIHSS score and mRS score, Barthel index score significantly increased (P0.05). The total effective rate of the combined treatment group was significantly higher than that of the routine treatment group (蠂 ~ 2 ~ 2 ~ 5.00 P0. 025). There were no significant adverse reactions in both groups. Conclusion for patients with acute cerebral infarction who can not be treated with thrombolytic therapy, routine therapy can improve the prognosis of the patients. On this basis, GM1 combined with hyperbaric oxygen therapy can effectively promote the rehabilitation and long-term effect of neurological function in patients with acute cerebral infarction, and it is safe and effective, and worthy of clinical promotion.
【作者單位】： 蘇州市第七人民醫(yī)院神經(jīng)內(nèi)科;蘇州大學(xué)附屬第二醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R743.3

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