【摘要】：目的觀察連續(xù)性血液凈化(CBP)治療嚴(yán)重膿毒癥患者的療效及對(duì)細(xì)胞因子的影響。方法回顧性分析60例嚴(yán)重膿毒癥并接受CBP患者的臨床資料,將其分為常規(guī)治療組與CBP治療組各30例。觀察并記錄兩組0、24、72 h血清中腫瘤壞死因子(TNF)-α、白細(xì)胞介素(IL)-1β、IL-6水平;此外比較兩組治療24 h的急性生理和慢性健康狀態(tài)評(píng)分(APACHE)Ⅱ評(píng)分、兩組需行機(jī)械通氣時(shí)間。結(jié)果 1在入院后經(jīng)CBP治療24、72 h患者血清中的TNF-α、IL-1β、IL-6濃度明顯下降(P0.05)。CBP治療組24、72 h患者血液中的TNF-α、IL-1β、IL-6濃度明顯低于常規(guī)治療組(P0.05)。2治療24 h兩組APACHEⅡ評(píng)分明顯降低,CBP治療組明顯低于常規(guī)治療組(P0.05)。3兩組需行機(jī)械通氣時(shí)間差異顯著(P0.01)。結(jié)論及早行CBP治療可以有效清除血液中的細(xì)胞因子,縮短機(jī)械通氣時(shí)間,改善疾病,提高患者預(yù)后。
[Abstract]:Objective to observe the effect of continuous blood purification (CBP) in the treatment of severe sepsis. Methods the clinical data of 60 patients with severe sepsis and CBP were analyzed retrospectively and divided into routine treatment group and CBP treatment group. The levels of tumor necrosis factor (TNF)-偽, interleukin (IL)-1 尾 and IL-6 were observed and recorded in the serum of the two groups for 72 h. In addition, the (APACHE) 鈪，

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