發(fā)布時間：2018-10-21 13:17

【摘要】：目的探討非心源性腦梗死患者急性期24 h血壓變異和早期神經(jīng)功能惡化的關系。方法采用病例對照研究方法連續(xù)登記急性非心源性腦梗死患者,收集一般臨床資料,連續(xù)血壓監(jiān)測并計算24 h血壓變異的各參數(shù),按照入院7 d內(nèi)有無發(fā)生腦梗死早期神經(jīng)功能惡化進行分組比較,建立Logistic回歸模型分析24 h血壓和血壓變異參數(shù)與早期神經(jīng)功能惡化的關系。結果 221例入組患者中59例(26.7%)出現(xiàn)早期神經(jīng)功能惡化。出現(xiàn)早期神經(jīng)功能惡化組24 h平均收縮壓和收縮壓變異系數(shù)顯著高于未發(fā)生組[(145.8±18.2)mm Hg vs.(139.9±20.3)mm Hg;9.0(7.3~11.2)vs.8.4(6.9~10.2)],差異均有統(tǒng)計學意義(P0.05)。多因素校正后,24 h平均收縮壓水平和收縮壓變異系數(shù)增大是發(fā)生早期神經(jīng)功能惡化的獨立危險因素(每10 mm Hg 24 h平均收縮壓OR=1.285,95%CI(1.059~1.559);收縮壓變異系數(shù)OR=1.206,95%CI(1.050~1.384))。結論入院后24 h收縮壓變異增大是急性非心源性腦梗死7 d內(nèi)發(fā)生早期神經(jīng)功能惡化的危險因素。
[Abstract]:Objective to investigate the relationship between 24 h blood pressure variation and early neurological deterioration in patients with non-cardiogenic cerebral infarction. Methods A case-control study was conducted to continuously register patients with acute non-cardiogenic cerebral infarction, to collect general clinical data, to monitor blood pressure continuously and to calculate the parameters of 24 h blood pressure variation. Logistic regression model was established to analyze the relationship between 24 h blood pressure and blood pressure variation parameters and the deterioration of early neurological function according to whether or not there was early neurological deterioration in patients with cerebral infarction within 7 days after admission. Results among 221 patients, 59 (26.7%) had early neurological deterioration. The mean systolic blood pressure and systolic blood pressure coefficient of variation were significantly higher in the group with early neurological deterioration than in the group without onset [(145.8 鹵18.2) mm Hg vs. (139.9 鹵20.3) mm Hg;9.0 (7.3n11.2) vs.8.4 (6.9 鹵10.2)], and the difference was statistically significant (P0.05). After multivariate adjustment, 24 h mean systolic blood pressure level and increased systolic blood pressure coefficient of variation were independent risk factors for early neurologic deterioration (10 mm Hg / 24 h mean systolic blood pressure OR=1.285,95%CI (1.059 鹵1.559); systolic blood pressure coefficient of variation OR=1.206,95%CI (1.050 鹵1.384).) Conclusion the increase of systolic blood pressure variation 24 hours after admission is a risk factor for early neurological deterioration within 7 days of acute non-cardiogenic cerebral infarction.
【作者單位】： 東莞市人民醫(yī)院神經(jīng)內(nèi)科;
【基金】：東莞市社會科技發(fā)展項目(編號:201650715000222) 廣東省醫(yī)學科學技術研究基金(編號:A2013836)
【分類號】：R743.3

【相似文獻】

相關期刊論文 前2條

1 秦琳;周其達;鄒錫良;潘曉帆;華鍵;韓楊;;血壓變異對急性腦梗死靜脈溶栓患者出血轉化的影響[J];中華臨床醫(yī)師雜志(電子版);2013年12期

2 ;[J];;年期

相關碩士學位論文 前2條

1 彭琳;腦出血急性期血腫擴大與血壓變異的關系[D];北京協(xié)和醫(yī)學院;2015年

2 葛中林;高血壓性腦出血早期血腫擴大與血壓指標的相關性研究[D];安徽醫(yī)科大學;2013年

，

本文編號：2285198