【摘要】：目的·研究急性腦梗死患者血清陷窩蛋白1(Cav-1)水平與早期神經(jīng)功能惡化(END)的關(guān)系。方法·選取2016年7月—2017年1月重慶醫(yī)科大學(xué)附屬第一醫(yī)院神經(jīng)內(nèi)科收治的急性腦梗死患者126例,ELISA法檢測血清Cav-1水平,同時(shí)采用美國國立衛(wèi)生研究院腦卒中量表(NIHSS)、格拉斯哥昏迷量表(GCS)評(píng)估患者神經(jīng)功能缺損程度。與入院NIHSS基線評(píng)分比較,若患者入院3 d內(nèi)第2次NIHSS運(yùn)動(dòng)評(píng)分項(xiàng)增加≥1分或總分增加≥2分,則歸入END組,否則歸入非END組。多因素Logistic回歸分析患者發(fā)生END的獨(dú)立預(yù)測因子,ROC曲線分析Cav-1預(yù)測END的準(zhǔn)確性。結(jié)果·END組血清Cav-1水平較非END組顯著升高[(29.88±19.57)ng/m L vs(16.08±13.37)ng/m L,P=0.000]。ROC曲線分析血清Cav-1預(yù)測END的最佳切點(diǎn)為16.55 ng/m L,靈敏度和特異度分別為73.33%和74.07%。Logistic分析顯示,Cav-1≥16.55 ng/m L是急性腦梗死患者發(fā)生END的獨(dú)立預(yù)測因子(OR=4.936,95%CI為1.608~15.155,P=0.005)。結(jié)論·血清Cav-1水平是急性腦梗死發(fā)生END的獨(dú)立預(yù)測因子。
[Abstract]:Objective to study the relationship between serum Cav-1 level and (END) in patients with acute cerebral infarction. Methods from July 2016 to January 2017, 126 patients with acute cerebral infarction treated in Department of Neurology, the first affiliated Hospital of Chongqing Medical University, were selected to detect serum Cav-1 level by Elisa. At the same time, (NIHSS), Glasgow coma scale (GCS) was used to assess the degree of neurological impairment. Compared with the baseline score of NIHSS in admission, if the NIHSS motor score of the second time within 3 days of admission was increased 鈮，

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