發(fā)布時(shí)間：2018-09-17 19:46

【摘要】：目的探討血清白細(xì)胞介素(IL)-18、IL-10與腫瘤壞死因子(TNF)-α對(duì)老年膿毒血癥患者預(yù)后的預(yù)測(cè)價(jià)值。方法選取該院2012年1月至2015年1月老年膿毒血癥患者89例,根據(jù)預(yù)后狀況將患者分為存活組(48例)與病死組(41例),采用酶聯(lián)免疫吸附法(ELISA)測(cè)定血清IL-18、IL-10、TNF-α水平。采用Pearson相關(guān)系數(shù)分析血清指標(biāo)與急性生理學(xué)與慢性健康狀況評(píng)估系統(tǒng)Ⅱ(APACHEⅡ)評(píng)分、序貫器官衰竭估計(jì)(SOFA)評(píng)分的關(guān)系,采用受試者工作特征曲線(ROC)及曲線下面積(AUC)分析血清指標(biāo)對(duì)老年膿毒血癥患者預(yù)后的預(yù)測(cè)價(jià)值。結(jié)果存活組血清IL-18、IL-10與TNF-α水平明顯低于病死組,APACHEⅡ評(píng)分、SOFA評(píng)分明顯低于病死組(P0.05)。經(jīng)Pearson相關(guān)系數(shù)分析顯示,IL-18、IL-10、TNF-α與APACHEⅡ評(píng)分、SOFA評(píng)分呈明顯正相關(guān)(P0.05)。ROC分析顯示,IL-18、IL-10、TNF-α的AUC分別為0.723、0.916、0.851(P0.05)。結(jié)論血清IL-18、IL-10與TNF-α對(duì)老年膿毒血癥患者預(yù)后具有重要的預(yù)測(cè)價(jià)值,其中血清IL-10預(yù)測(cè)價(jià)值最佳。
[Abstract]:Objective to investigate the prognostic value of serum interleukin (IL)-18 sil-10 and tumor necrosis factor (TNF)-偽 in elderly patients with sepsis. Methods Eighty-nine elderly patients with sepsis from January 2012 to January 2015 were divided into survival group (48 cases) and dead group (41 cases) according to their prognosis. Serum IL-18,IL-10,TNF- 偽 levels were measured by Elisa (ELISA). Pearson correlation coefficient was used to analyze the relationship between serum index and acute physiology and chronic health assessment system 鈪，

本文編號(hào)：2246904