【摘要】：目的:評(píng)價(jià)微小RNA(miRNAs)對(duì)中國(guó)急性心肌梗死(AMI)患者的早期診斷價(jià)值。方法:采用Cochrane系統(tǒng)評(píng)價(jià)的基本方法,全面檢索Pubmed、Medline、Web of science、中國(guó)期刊全網(wǎng)全文數(shù)據(jù)庫(kù)(CNKI)、萬(wàn)方數(shù)據(jù)庫(kù)、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù),無(wú)語(yǔ)言限制,搜集評(píng)價(jià)miRNAs對(duì)中國(guó)AMI患者診斷價(jià)值的文獻(xiàn),以靈敏度(Sen)、特異度(Spe)、診斷優(yōu)勢(shì)比(DOR)及受試者工作特征曲線(xiàn)下面積(SROC)作為診斷效能的評(píng)價(jià)指標(biāo),采用MetaDisc1.4軟件進(jìn)行系統(tǒng)評(píng)價(jià)和Meta分析。結(jié)果:共納入24篇文獻(xiàn),其中英文15篇,中文9篇。Meta分析結(jié)果顯示:總miRNAs的合并Sen、Spe和SROC面積分別為0.73(95%CI:0.72~0.75)、0.82(95%CI:0.81~0.84)和0.8783;miRNA-499的合并Sen、Spe和SROC面積為0.78(95%CI:0.75~0.81)、0.76(95%CI:0.72~0.79)和0.8781;miRNA-1的合并Sen、Spe和SROC面積為0.73(95%CI:0.69~0.78)、0.84(95%CI:0.80~0.87)和0.8374;miRNA-208的合并Sen、Spe和SROC面積為0.73(95%CI:0.68~0.77)、0.85(95%CI:0.80~0.88)和0.8658;miRNA-133的合并Sen、Spe和SROC面積為0.75(95%CI:0.70~0.80)、0.88(95%CI:0.84~0.92)和0.9391。結(jié)論:miRNA是一種新型的心臟損傷標(biāo)志物,尤其miRNA-133對(duì)早期A(yíng)MI具有較強(qiáng)的診斷價(jià)值,但仍需要更大樣本高質(zhì)量的臨床試驗(yàn)加以驗(yàn)證。
[Abstract]:Objective: to evaluate the value of small RNA (miRNAs) in early diagnosis of (AMI) patients with acute myocardial infarction in China. Methods: the basic method of Cochrane system evaluation was used to search the Pubmed,Medline,Web of science, full text database of Chinese periodicals, (CNKI), Wanfang database and Chinese biomedical literature database without language restriction. Literature on the diagnostic value of miRNAs in Chinese AMI patients was collected. The diagnostic advantage ratio of sensitivity (Sen), specificity to (Spe), and the area (SROC) under the operating characteristic curve of the subjects were used as the evaluation index of diagnostic efficacy. MetaDisc1.4 software was used for systematic evaluation and Meta analysis. Results: a total of 24 articles were included, 15 of which were in English and Chinese. 涓枃9綃，

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