【摘要】：目的:探索β-fib基因多態(tài)性與中國漢族人群前交叉韌帶(anterior cruciate ligament,ACL)損傷發(fā)生的關(guān)系。方法:收集105名ACL損傷的漢族患者,以110名無ACL損傷史的漢族個體作為對照,通過限制性片段長度多態(tài)性(restriction fragment length polymorphism,RFLP)分析、測序技術(shù)對β-fib基因啟動子區(qū)單核苷酸多態(tài)性(single nucleotide polymorphisms,SNPs)進行檢測并分型,開展病例對照關(guān)聯(lián)分析。結(jié)果:β-fib基因啟動子區(qū)共檢出6個SNPs,包括;β-148C/T(rs1800787)、β-249C/T(rs1800788)、β-455G/A(rs1800790)、β-854G/A(rs1800791)、β-933G/A(rs2227389)、β-1420G/A(rs1800789),其中rs1800790、rs1800788和rs1800787的AG、CT和CT基因表型頻率在病例組中高于對照組(P0.05)。rs2227389-rs1800791-rs1800790單倍型C G A*、T G A*、T G G*在病例組和對照組中也顯示統(tǒng)計學差異。結(jié)論:在中國漢族人群,β-fib基因啟動子區(qū)rs1800790、rs1800788和rs1800787及其單倍型可能與ACL損傷的發(fā)生相關(guān)。
[Abstract]:Objective: to investigate the relationship between 尾 -fib gene polymorphism and anterior cruciate ligament (anterior cruciate ligament,ACL) injury in Chinese Han population. Methods: a total of 105 Han patients with ACL damage and 110 Han individuals with no history of ACL damage were collected and analyzed by restriction fragment length polymorphism (restriction fragment length polymorphism,RFLP). The single nucleotide polymorphisms (single nucleotide polymorphisms,SNPs) of 尾 -fib gene promoter were detected and typed by sequencing, and case-control analysis was carried out. 緇撴灉:尾-fib鍩哄洜鍚姩瀛愬尯鍏辨鍑，

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