【摘要】：目的觀察參麥注射液輔助治療急性心肌梗死的臨床療效及安全性。方法將72例急性心肌梗死患者隨機(jī)分為對(duì)照組35例和試驗(yàn)組37例。對(duì)照組予以吸氧、抗凝、抗血小板等治療;試驗(yàn)組在對(duì)照組治療的基礎(chǔ)上,予以靜脈滴注參麥注射液20 mL qd。2組患者均治療2周。比較2組患者的臨床療效和藥物不良反應(yīng)的發(fā)生情況。結(jié)果治療后,試驗(yàn)組和對(duì)照組的總有效率分別為89.19%(33/37例)和71.43%(25/35例),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,試驗(yàn)組和對(duì)照組的左心室射血分?jǐn)?shù)(LVEF)分別為(72.16±16.44)%,(58.43±20.06)%;E峰值分別為(88.40±8.89),(68.19±6.87)cm·s~(-1);E/A值分別為(1.27±0.13),(0.98±0.10),差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,試驗(yàn)組和對(duì)照組的A峰值分別為(69.61±7.03),(69.58±7.01)cm·s~(-1),差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療期間,試驗(yàn)組發(fā)生的藥物不良反應(yīng)有口干、過(guò)敏、惡心,對(duì)照組發(fā)生的藥物不良反應(yīng)有口干、過(guò)敏、頭痛。試驗(yàn)組和對(duì)照組的藥物不良反應(yīng)率分別為13.51%和8.57%,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論參麥注射液輔助治療急性心肌梗死有很好的臨床療效,且不增加藥物不良反應(yīng)的發(fā)生率。
[Abstract]:Objective to observe the clinical efficacy and safety of Shenmai injection in the treatment of acute myocardial infarction. Methods 72 patients with acute myocardial infarction were randomly divided into control group (n = 35) and trial group (n = 37). The control group was treated with oxygen inhalation, anticoagulant and anti-platelet therapy, and the experimental group was treated with 20 mL Shenmai injection by intravenous drip for 2 weeks on the basis of the control group. The clinical efficacy and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 89.19% (33 / 37 cases) and 71.43% (25 / 35 cases), respectively. The difference was statistically significant (P0.05). After treatment, the left ventricular ejection fraction (LVEF) was (72.16 鹵16.44) and (58.43 鹵20.06) the peak value of E was (88.40 鹵8.89), (, 68.19 鹵6.87) cm s-1 / A (1.27 鹵0.13), (0.98 鹵0.10) in the experimental group and the control group, respectively (P0.05). After treatment, the A peak value of experimental group and control group was (69.61 鹵7.03), (鹵69.58 鹵7.01) cm s ~ (-1), the difference was not statistically significant (P0.05). During treatment, the adverse drug reactions occurred in the trial group were dry mouth, allergic, nausea, and the adverse drug reactions in the control group were dry mouth, allergy and headache. The adverse drug reaction rates of the test group and the control group were 13.51% and 8.57%, respectively. The difference was not statistically significant (P0.05). Conclusion Shenmai injection is effective in the treatment of acute myocardial infarction and does not increase the incidence of adverse drug reactions.
【作者單位】： 黔南布依族苗族自治州人民醫(yī)院心內(nèi)科;貴州航空集團(tuán)300醫(yī)院心內(nèi)科;
【基金】：黔南民族醫(yī)學(xué)高等專(zhuān)科學(xué)�？蒲谢鹳Y助項(xiàng)目(QNYZ2014-21)
【分類(lèi)號(hào)】：R542.22

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