【摘要】：目的分析急性顱腦損傷不同程度不同時(shí)間段患者血糖、胰島素水平關(guān)系及血清白細(xì)胞介素6（IL-6）和白介素10（IL-10）的含量變化及臨床意義。方法106例急性顱腦損傷患者按入院時(shí)GCS評(píng)分分為輕度、中度和重度三組，分別于傷后1d、2d、3d、4d、5d測(cè)定空腹血糖、血清胰島素值并計(jì)算胰島素抵抗指數(shù)（HOMA-IR），分析急性顱腦損傷程度與HOMA-IR之間關(guān)系；在采用酶聯(lián)免疫吸附（ELISA）法測(cè)定血清IL-6、IL-10含量，根據(jù)IL-6、IL-10的動(dòng)態(tài)變化，分析急性顱腦損傷程度與血清IL-6、IL-10含量之間關(guān)系。結(jié)果不同程度的急性顱腦損傷患者血糖、胰島素水平及HOMA-IR有顯著差異（Ｐ0.01,Ｐ0.05），血糖、血清胰島素和HOMA-IR越高，急性顱腦損傷的程度越重，同時(shí)血清IL-6含量在傷后高于對(duì)照組（P0.05），而在重型顱腦損傷中增高較輕型和中型損傷更為明顯（P0.05）。不同程度的急性顱腦損傷患者血清IL-10含量在傷后高于對(duì)照組（P0.05），，而在重型顱腦損傷中增高較輕型和中型損傷更為明顯（P0.05）結(jié)論空腹血糖值、HOMA-IR及血清IL-6、IL-10含量與急性顱腦損傷程度存在相關(guān)性，可作為評(píng)估急性顱腦損傷嚴(yán)重程度及預(yù)后的一個(gè)客觀指標(biāo)。
[Abstract]:Objective to analyze the relationship between blood glucose, insulin and serum interleukin 6 (IL-6) and interleukin 10 (IL-10) levels in patients with acute craniocerebral injury. Methods 106 patients with acute craniocerebral injury were divided into mild, moderate and severe groups according to the GCS score at admission. Fasting blood glucose levels were measured at 2 days, 3 days, 4 days and 5 days after injury, respectively. Serum insulin level and insulin resistance index (HOMA-IR) were calculated to analyze the relationship between the degree of acute craniocerebral injury and HOMA-IR, the level of IL-10 in serum was determined by enzyme-linked immunosorbent assay (ELISA), and the dynamic changes of IL-10 were observed according to the level of IL-6. To analyze the relationship between the degree of acute craniocerebral injury and the level of IL-10 in serum. Results there were significant differences in blood glucose, insulin level and HOMA-IR in patients with acute craniocerebral injury (P0.01P 0.05). The higher the blood glucose, serum insulin and HOMA-IR were, the more severe the acute craniocerebral injury was. At the same time, the level of serum IL-6 was higher after injury than that in control group (P0.05), but it was higher in severe craniocerebral injury than that in mild and moderate injury (P0.05). The level of serum IL-10 in patients with acute craniocerebral injury of different degrees was higher than that in control group (P0.05), but it was significantly higher in severe craniocerebral injury than that in mild and moderate injury (P0.05). Conclusion fasting blood glucose level, HOMA-IR and serum IL-6 IL-10 levels in patients with acute craniocerebral injury are significantly higher than those in patients with acute craniocerebral injury. There is a correlation between the degree of injury, It can be used as an objective index to evaluate the severity and prognosis of acute craniocerebral injury.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R651.15

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